International workshop: Radiation effects on mutation in somatic and germline stem cells

Purpose: New developments in knowledge of radiation effects on tissue stem cells were discussed in a Workshop held at the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan, 18-19 January 2012. Results: Stem cells and their niche in intestinal mucosa, haemopoietic tissue, hair follicle...

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Bibliographic Details
Published in:International journal of radiation biology 2012-06, Vol.88 (6), p.501-506
Main Authors: Kodama, Yoshiaki, Noda, Asao, Booth, Catherine, Breault, David, Suda, Toshio, Hendry, Jolyon, Shinohara, Takashi, Rübe, Claudia, Nishimura, Emi K., Mitani, Hiroshi, Nakamura, Nori, Niwa, Ohtsura
Format: Article
Language:English
Subjects:
age-dependent effects
Animals
Germ-Line Mutation
hereditary effects
Humans
Male
Mutation
mutations
protection
Radiation Injuries - genetics
Radiation Tolerance
Regeneration
Spermatogenesis - genetics
Spermatogenesis - radiation effects
Stem Cell Niche - genetics
Stem Cell Niche - physiology
Stem Cell Niche - radiation effects
Stem Cells - radiation effects
Stem cells and niche
tissue radiation responses
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Summary:Purpose: New developments in knowledge of radiation effects on tissue stem cells were discussed in a Workshop held at the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan, 18-19 January 2012. Results: Stem cells and their niche in intestinal mucosa, haemopoietic tissue, hair follicles, and spermatogenesis were discussed variously with regard to radiosensitivity, repair, regeneration, age-dependency of effects, genetic effects, and protection aspects. These tissues all possess a common basic template, but there are structural and hierarchical differences between tissues which continue to be elucidated in terms of a stem-cell age structure and niche regulatory signals which together govern radiation responses. Conclusions: Stem cells and their niche have become much better characterized in recent years, and their radiation response can be elucidated in detail in experimental systems to help underpin both protection and therapeutic recommendations established from human epidemiological evidence. This report summarizes the presentations at the meeting, and concludes with some remaining questions which may be answered with the help of this type of research.
ISSN:0955-3002
1362-3095
DOI:10.3109/09553002.2012.683512