Static magnetic field attenuates lipopolysaccharide-induced multiple organ failure: A histopathologic study in mice

Abstract Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ fail...

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Bibliographic Details
Published in:International journal of radiation biology 2015-02, Vol.91 (2), p.135-141
Main Authors: Lai, Wei-Yi, Huang, Yu-Chih, Chang, Wei-Jen, Wang, Hsin-Ta, Fong, Tsorng-Harn, Lin, Che-Tong, Huang, Haw-Ming
Format: Article
Language:English
Subjects:
Animals
histopathology
Kidney Cortex - drug effects
Kidney Cortex - pathology
lipopolysaccharide
Lipopolysaccharides - adverse effects
Liver - drug effects
Liver - pathology
Magnetic Fields
Male
Mice
Mice, Inbred BALB C
multiple organ failure
Multiple Organ Failure - chemically induced
Multiple Organ Failure - pathology
Multiple Organ Failure - therapy
Space life sciences
Static magnetic field
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Summary:Abstract Purpose: Previous studies demonstrated that static magnetic fields (SMF) were effective in down-regulating the expression of lipopolysaccharide (LPS)-induced inflammatory cytokines. The aim of this study was to provide histological evidence of SMF attenuating LPS-induced multiple organ failure (MOF). Materials and methods: In this study, BALB/cByJNarl (5 weeks, weighing 20-25 g) mice were chosen as test subjects. The tested animals were challenged with 50 mg/kg LPS after they were exposed to a continuous SMF for 2 h. The survival rate and pathological changes in lungs, kidneys, and livers of the LPS- challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on body temperature control of the LPS-challenged mice were monitored. Results: Our results showed that at 30 h the survival rate of LPS-challenged mice increased 3.6-fold (p < 0.05). In addition, 6 h after LPS injection, the average body temperature of SMF-exposed mice was 1.07°C lower than that of unexposed animals. Tissue biopsies demonstrated that SMF exposure reduced damage to the lungs, livers, and kidneys in the LPS-challenged mice. Conclusions: SMF show potential as a viable prophylactic alternative for controlling LPS-induced MOF.
ISSN:0955-3002
1362-3095
DOI:10.3109/09553002.2015.959669