Comparison of PLGA and lecithin/chitosan nanoparticles for dermal targeting of betamethasone valerate

Abstract Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution an...

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Bibliographic Details
Published in:Journal of drug targeting 2013-07, Vol.21 (6), p.542-550
Main Authors: Özcan, pek, Azizo lu, Erkan, enyi it, Taner, Özyaz c, Mine, Özer, Özgen
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - chemistry
Betamethasone valerate
Betamethasone Valerate - administration & dosage
Betamethasone Valerate - chemistry
Betamethasone Valerate - pharmacokinetics
Chemistry, Pharmaceutical - methods
Chitosan - administration & dosage
Chitosan - chemistry
Chitosan - pharmacokinetics
Dermis - drug effects
Dermis - metabolism
Drug Delivery Systems - methods
Epidermis - drug effects
Epidermis - metabolism
in-vivo evaluation
Lactic Acid - administration & dosage
Lactic Acid - chemistry
lecithin/chitosan nanoparticles
Lecithins - administration & dosage
Lecithins - chemistry
Lecithins - pharmacokinetics
Male
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanoparticles - metabolism
Particle Size
Permeability - drug effects
PLGA nanoparticles
Polyglycolic Acid - administration & dosage
Polyglycolic Acid - chemistry
Rats
Rats, Wistar
Skin Absorption - drug effects
skin permeation
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Summary:Abstract Poly(lactide-co-glycolide) (PLGA) and lecithin/chitosan (LC) nanoparticles were prepared to evaluate the difference in the behavior upon administration on skin, for steroidal treatment. For this purpose, betamethasone-17-valerate (BMV)-loaded nanoparticles with a narrow size distribution and high entrapment efficiency were prepared. Permeation studies showed that both polymeric nanoparticles enhanced the amount of BMV in epidermis, which is the target site of topical steroidal treatment, when compared with commercial formulation. 1.58-Fold increase was determined in the epidermis concentration of BMV by LC nanoparticles with respect to PLGA nanoparticles. Nanoparticles were diluted in chitosan gel (10%, w/w) to prepare suitable formulation for topical application. Accumulation from both gel formulations were found significantly higher than commercial formulation in skin layers (p 
ISSN:1061-186X
1029-2330
DOI:10.3109/1061186X.2013.769106