Free radicals and acute pancreatitis: Much ado about ... something

Abstract There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic da...

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Bibliographic Details
Published in:Free radical research 2013-11, Vol.47 (11), p.934-940
Main Author: Closa, Daniel
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Free Radicals - metabolism
Humans
Lipid Peroxidation
oxidative damage
Oxidative Stress - physiology
pancreatitis
Pancreatitis - drug therapy
Pancreatitis - metabolism
Pancreatitis, Acute Necrotizing - metabolism
reactive oxygen species
Reactive Oxygen Species - metabolism
xanthine dehydrogenase/xanthine oxidase
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Summary:Abstract There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is also involved in the progression of the disease from a local damage to a systemic organ failure. However, therapeutic use of antioxidants failed to clearly show a clinical benefit in different trials. Therefore, although antioxidants alone seem to be not enough for the treatment of severe acute pancreatitis, future combined therapeutic strategies should include antioxidants in its composition.
ISSN:1071-5762
1029-2470
DOI:10.3109/10715762.2013.829571