Infant Neurobehavior Following Prenatal Exposure to Methadone or Buprenorphine: Results From the Neonatal Intensive Care Unit Network Neurobehavioral Scale

This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n = 11) or buprenorphine (n = 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses...

Full description

Saved in:
Bibliographic Details
Published in:Substance use & misuse 2010-11, Vol.45 (13), p.2244-2257
Main Authors: Jones, Hendrée E., O'Grady, Kevin E., Johnson, Rolley E., Velez, Martha, Jansson, Lauren M.
Format: Article
Language:English
Subjects:
Abstinence
Adult
Akathisia, Drug-Induced - drug therapy
Babies
Behavior
Buprenorphine
Buprenorphine - adverse effects
developmental neurobehavior
Drug therapy
Drug use
Female
Humans
Infant, Newborn
Infants
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Lethargy
Male
Methadone
Methadone - adverse effects
Narcotics - adverse effects
neonatal abstinence syndrome
Neonatal care
Neonatal units
Newborn babies
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
Quality of Health Care
Randomized Controlled Trials as Topic
substance abuse
Surveys and Questionnaires
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n = 11) or buprenorphine (n = 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses revealed that NNNS scores of arousal and excitability showed significant differences between medications over time. Compared to neonates who did not require medication to treat neonatal abstinence syndrome (NAS), neonates receiving pharmacotherapy for NAS showed differences over time in quality of movement, excitability, and lethargy. Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS.
ISSN:1082-6084
1532-2491
DOI:10.3109/10826084.2010.484474