A novel tool for the prediction of tablet sticking during high speed compaction

During tableting, capping is a problem of cohesion while sticking is a problem of adhesion. Sticking is a multi-composite problem; causes are either material or machine related. Nowadays, detecting such a problem is a pre-requisite in the early stages of development. The aim of our study was to inve...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2012-11, Vol.17 (6), p.747-754
Main Authors: Abdel-Hamid, Sameh, Betz, Gabriele
Format: Article
Language:English
Subjects:
adhesion
compaction simulation
Compressive Strength
Drug Compounding - instrumentation
Drug Compounding - methods
Drug Industry - instrumentation
Drug Industry - methods
Excipients - chemistry
Mefenamic acid
Mefenamic Acid - chemistry
Particle Size
Porosity
Powders - chemistry
Pressure
radial die-wall pressure
Sticking
Surface Properties
Tablets - chemistry
Tensile Strength
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Summary:During tableting, capping is a problem of cohesion while sticking is a problem of adhesion. Sticking is a multi-composite problem; causes are either material or machine related. Nowadays, detecting such a problem is a pre-requisite in the early stages of development. The aim of our study was to investigate sticking by radial die-wall pressure monitoring guided by compaction simulation. This was done by using the highly sticking drug; Mefenamic acid (MA) at different drug loadings with different fillers compacted at different pressures and speeds. By increasing MA loading, we found that viscoelastic fillers showed high residual radial pressure after compaction while plastic/brittle fillers showed high radial pressure during compaction, p 
ISSN:1083-7450
1097-9867
DOI:10.3109/10837450.2011.580761