Treatment of melasma with a depigmentation cream determined with colorimetry

Abstract Background. Melasma is a pigmentary disorder often recalcitrant to treatment. Few studies have objectively evaluated the efficacy of treatment colorimetrically. Aim. To evaluate the safety and efficacy of a depigmentation cream, including mainly glycolic acid and Rumex occidentalis. Method....

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Bibliographic Details
Published in:Journal of cosmetic and laser therapy 2011-10, Vol.13 (5), p.255-259
Main Authors: Sabancilar, Emine, Aydin, Fatma, Bek, Yuksel, Ozden, Muge Guler, Ozcan, Muharrem, Senturk, Nilgün, Canturk, Tayyar, Turanli, Ahmet Yasar
Format: Article
Language:English
Subjects:
Adult
Colorimetry
depigmentation cream
Drug Combinations
Female
Glycolates - adverse effects
Glycolates - therapeutic use
glycolic acid
Humans
Male
Melanosis - drug therapy
melasma
Middle Aged
Phytotherapy
Plant Preparations - adverse effects
Plant Preparations - therapeutic use
Polygonaceae - adverse effects
Treatment Outcome
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Summary:Abstract Background. Melasma is a pigmentary disorder often recalcitrant to treatment. Few studies have objectively evaluated the efficacy of treatment colorimetrically. Aim. To evaluate the safety and efficacy of a depigmentation cream, including mainly glycolic acid and Rumex occidentalis. Method. Twenty-seven patients applied the cream twice daily for the first 3 months and twice weekly for the following 3 months. L*, C* and h* values of the target lesions and the perilesional area were analyzed at baseline, 12 and 24 weeks colorimetrically. The physician and patient evaluated the clinical response rate. These results were compared statistically between the lesional and perilesional area. Results. There was a significant difference between 0-12, 0-24 (L*, C* and h* values) and 12-24 weeks (L* value) (p
ISSN:1476-4172
1476-4180
DOI:10.3109/14764172.2011.606463