The relationship between trough drug concentrations and ductal closure in preterm infants treated with three-dose-oral ibuprofen

Abstract The aim of the present study was to characterize the pharmacokinetic profile of oral ibuprofen on consecutive 3 d by trough serum levels, and if possible to define a cut-off level for ductal closure in preterm infants. The study enrolled 20 preterm infants with gestational age 30 weeks, bir...

Full description

Saved in:
Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2013-09, Vol.26 (13), p.1306-1310
Main Authors: Yurttutan, Sad k, Erdeve, Omer, Oncel, Mehmet Yekta, Ozdemir, Ramazan, Dilmen, Ugur
Format: Article
Language:English
Subjects:
Administration, Oral
Birth Weight - physiology
Concentration
Dose-Response Relationship, Drug
Ductus Arteriosus, Patent - blood
Ductus Arteriosus, Patent - drug therapy
Ductus Arteriosus, Patent - metabolism
Female
Gestational Age
Humans
ibuprofen
Ibuprofen - administration & dosage
Ibuprofen - blood
Ibuprofen - pharmacokinetics
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - drug therapy
Infant, Premature, Diseases - metabolism
Male
oral
Osmolar Concentration
patent ductus arteriosus
pharmacokinetics
preterm
Remission Induction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The aim of the present study was to characterize the pharmacokinetic profile of oral ibuprofen on consecutive 3 d by trough serum levels, and if possible to define a cut-off level for ductal closure in preterm infants. The study enrolled 20 preterm infants with gestational age 30 weeks, birth weight
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.784739