Relationship between neonatal adrenomedullin and bilirubin levels

Abstract Introduction: Oxidative stress and inflammation are the basic molecular mechanisms in bilirubin neurotoxicity. We aimed to investigate the relationship between serum bilirubin and an antioxidant, anti-inflammatory and neuroprotective peptid, adrenomedullin (AM) levels. Methods: The correlat...

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2014-01, Vol.27 (1), p.30-35
Main Authors: Erdinc, Kemal, Sarici, S. Umit, Akgul, E. Ozgur, Agilli, Mehmet, Ozcan, Okan
Format: Article
Language:English
Subjects:
Adrenomedullin
Adrenomedullin - blood
bilirubin
Bilirubin - blood
Case-Control Studies
Female
Humans
Hyperbilirubinemia - blood
Hyperbilirubinemia - complications
Infant, Newborn
Jaundice, Neonatal - etiology
Jaundice, Neonatal - therapy
Male
newborn
Phototherapy
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Summary:Abstract Introduction: Oxidative stress and inflammation are the basic molecular mechanisms in bilirubin neurotoxicity. We aimed to investigate the relationship between serum bilirubin and an antioxidant, anti-inflammatory and neuroprotective peptid, adrenomedullin (AM) levels. Methods: The correlation between serum bilirubin and AM levels was investigated in a total of 87 newborns. Newborns were further divided into two groups according to the serum bilirubin levels. Group I (with significant hyperbilirubinemia) and Group II (without significant hyperbilirubinemia) were compared with respect to demographic, anthropometric and biochemical parameters including serum AM levels. Results: In the correlation analysis, a significant positive correlation was detected between serum indirect bilirubin and AM levels in 87 newborns (p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.799655