Does transient hypothyroxinemia influence metabolic bone disease of prematurity?

Abstract Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP). Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded....

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Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine 2013-12, Vol.26 (18), p.1844-1849
Main Authors: Demirel, Utku, Özek, Eren, Bereket, Abdullah, Demirel, Bilge, Topuzo lu, Ahmet, Akman, pek
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Birth Weight
Bone Diseases, Metabolic - blood
Bone Diseases, Metabolic - complications
Bone Diseases, Metabolic - congenital
Bone Diseases, Metabolic - epidemiology
Bone Diseases, Metabolic - therapy
Congenital Hypothyroidism - blood
Congenital Hypothyroidism - complications
Congenital Hypothyroidism - epidemiology
Congenital Hypothyroidism - therapy
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature, Diseases - blood
Infant, Premature, Diseases - epidemiology
Infant, Premature, Diseases - therapy
Length of Stay - statistics & numerical data
metabolic bone disease
Parenteral Nutrition
prematurity
Respiration, Artificial
Thyroid Function Tests
thyroid hormones
Thyroxine - blood
transient hypothyroxinemia
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Summary:Abstract Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP). Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level 900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day. Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age. Conclusion: The risk of MBD does not increase significantly in babies with THOP.
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.804051