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Does transient hypothyroxinemia influence metabolic bone disease of prematurity?
Abstract Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP). Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded....
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| Published in: | The journal of maternal-fetal & neonatal medicine 2013-12, Vol.26 (18), p.1844-1849 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c418t-b6aec64614bcd93f82b592b9ad29b055984283d4ed874d582726ccf829795c093 |
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| cites | cdi_FETCH-LOGICAL-c418t-b6aec64614bcd93f82b592b9ad29b055984283d4ed874d582726ccf829795c093 |
| container_end_page | 1849 |
| container_issue | 18 |
| container_start_page | 1844 |
| container_title | The journal of maternal-fetal & neonatal medicine |
| container_volume | 26 |
| creator | Demirel, Utku Özek, Eren Bereket, Abdullah Demirel, Bilge Topuzo lu, Ahmet Akman, pek |
| description | Abstract
Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).
Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level 900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.
Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.
Conclusion: The risk of MBD does not increase significantly in babies with THOP. |
| doi_str_mv | 10.3109/14767058.2013.804051 |
| format | article |
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Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).
Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5 mg/dl and/or ALP >900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.
Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.
Conclusion: The risk of MBD does not increase significantly in babies with THOP.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.3109/14767058.2013.804051</identifier><identifier>PMID: 23672243</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Alkaline phosphatase ; Birth Weight ; Bone Diseases, Metabolic - blood ; Bone Diseases, Metabolic - complications ; Bone Diseases, Metabolic - congenital ; Bone Diseases, Metabolic - epidemiology ; Bone Diseases, Metabolic - therapy ; Congenital Hypothyroidism - blood ; Congenital Hypothyroidism - complications ; Congenital Hypothyroidism - epidemiology ; Congenital Hypothyroidism - therapy ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature, Diseases - blood ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - therapy ; Length of Stay - statistics & numerical data ; metabolic bone disease ; Parenteral Nutrition ; prematurity ; Respiration, Artificial ; Thyroid Function Tests ; thyroid hormones ; Thyroxine - blood ; transient hypothyroxinemia</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2013-12, Vol.26 (18), p.1844-1849</ispartof><rights>2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-b6aec64614bcd93f82b592b9ad29b055984283d4ed874d582726ccf829795c093</citedby><cites>FETCH-LOGICAL-c418t-b6aec64614bcd93f82b592b9ad29b055984283d4ed874d582726ccf829795c093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23672243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demirel, Utku</creatorcontrib><creatorcontrib>Özek, Eren</creatorcontrib><creatorcontrib>Bereket, Abdullah</creatorcontrib><creatorcontrib>Demirel, Bilge</creatorcontrib><creatorcontrib>Topuzo lu, Ahmet</creatorcontrib><creatorcontrib>Akman, pek</creatorcontrib><title>Does transient hypothyroxinemia influence metabolic bone disease of prematurity?</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Abstract
Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).
Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5 mg/dl and/or ALP >900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.
Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.
Conclusion: The risk of MBD does not increase significantly in babies with THOP.</description><subject>Alkaline phosphatase</subject><subject>Birth Weight</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Bone Diseases, Metabolic - complications</subject><subject>Bone Diseases, Metabolic - congenital</subject><subject>Bone Diseases, Metabolic - epidemiology</subject><subject>Bone Diseases, Metabolic - therapy</subject><subject>Congenital Hypothyroidism - blood</subject><subject>Congenital Hypothyroidism - complications</subject><subject>Congenital Hypothyroidism - epidemiology</subject><subject>Congenital Hypothyroidism - therapy</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Premature, Diseases - therapy</subject><subject>Length of Stay - statistics & numerical data</subject><subject>metabolic bone disease</subject><subject>Parenteral Nutrition</subject><subject>prematurity</subject><subject>Respiration, Artificial</subject><subject>Thyroid Function Tests</subject><subject>thyroid hormones</subject><subject>Thyroxine - blood</subject><subject>transient hypothyroxinemia</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMorq7-A5EevXRN0qRtLi6yfsKCHvQc0nTKZmmbNUnR_ntbdlfwsqcZhmfeGR6ErgieJQSLW8KyNMM8n1FMklmOGebkCJ2N45gJzo53_chM0Ln3a4wpGahTNKFJmlHKkjP0_mDBR8Gp1htoQ7TqNzasemd_TAuNUZFpq7qDVkPUQFCFrY2OCttCVBoPykNkq2jjoFGhcyb08wt0Uqnaw-WuTtHn0-PH4iVevj2_Lu6XsWYkD3GRKtApSwkrdCmSKqcFF7QQqqSiwJyLnNE8KRmUecZKntOMploPmMgE11gkU3Szzd04-9WBD7IxXkNdqxZs5yVhXBDOM5EOKNui2lnvHVRy40yjXC8JlqNLuXcpR5dy63JYu95d6IoGyr-lvbwBmG-BwZF1jfq2ri5lUH1tXTUY1caP8QdP3P1LWIGqw0orB3JtO9cOAg__-Auy1Jbr</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Demirel, Utku</creator><creator>Özek, Eren</creator><creator>Bereket, Abdullah</creator><creator>Demirel, Bilge</creator><creator>Topuzo lu, Ahmet</creator><creator>Akman, pek</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Does transient hypothyroxinemia influence metabolic bone disease of prematurity?</title><author>Demirel, Utku ; Özek, Eren ; Bereket, Abdullah ; Demirel, Bilge ; Topuzo lu, Ahmet ; Akman, pek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-b6aec64614bcd93f82b592b9ad29b055984283d4ed874d582726ccf829795c093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alkaline phosphatase</topic><topic>Birth Weight</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Bone Diseases, Metabolic - complications</topic><topic>Bone Diseases, Metabolic - congenital</topic><topic>Bone Diseases, Metabolic - epidemiology</topic><topic>Bone Diseases, Metabolic - therapy</topic><topic>Congenital Hypothyroidism - blood</topic><topic>Congenital Hypothyroidism - complications</topic><topic>Congenital Hypothyroidism - epidemiology</topic><topic>Congenital Hypothyroidism - therapy</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Infant, Premature, Diseases - epidemiology</topic><topic>Infant, Premature, Diseases - therapy</topic><topic>Length of Stay - statistics & numerical data</topic><topic>metabolic bone disease</topic><topic>Parenteral Nutrition</topic><topic>prematurity</topic><topic>Respiration, Artificial</topic><topic>Thyroid Function Tests</topic><topic>thyroid hormones</topic><topic>Thyroxine - blood</topic><topic>transient hypothyroxinemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demirel, Utku</creatorcontrib><creatorcontrib>Özek, Eren</creatorcontrib><creatorcontrib>Bereket, Abdullah</creatorcontrib><creatorcontrib>Demirel, Bilge</creatorcontrib><creatorcontrib>Topuzo lu, Ahmet</creatorcontrib><creatorcontrib>Akman, pek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demirel, Utku</au><au>Özek, Eren</au><au>Bereket, Abdullah</au><au>Demirel, Bilge</au><au>Topuzo lu, Ahmet</au><au>Akman, pek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does transient hypothyroxinemia influence metabolic bone disease of prematurity?</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2013-12</date><risdate>2013</risdate><volume>26</volume><issue>18</issue><spage>1844</spage><epage>1849</epage><pages>1844-1849</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Abstract
Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).
Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age 34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T4, total T4, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5 mg/dl and/or ALP >900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.
Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.
Conclusion: The risk of MBD does not increase significantly in babies with THOP.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>23672243</pmid><doi>10.3109/14767058.2013.804051</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1476-7058 |
| ispartof | The journal of maternal-fetal & neonatal medicine, 2013-12, Vol.26 (18), p.1844-1849 |
| issn | 1476-7058 1476-4954 |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Alkaline phosphatase Birth Weight Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - complications Bone Diseases, Metabolic - congenital Bone Diseases, Metabolic - epidemiology Bone Diseases, Metabolic - therapy Congenital Hypothyroidism - blood Congenital Hypothyroidism - complications Congenital Hypothyroidism - epidemiology Congenital Hypothyroidism - therapy Female Gestational Age Humans Infant, Newborn Infant, Premature, Diseases - blood Infant, Premature, Diseases - epidemiology Infant, Premature, Diseases - therapy Length of Stay - statistics & numerical data metabolic bone disease Parenteral Nutrition prematurity Respiration, Artificial Thyroid Function Tests thyroid hormones Thyroxine - blood transient hypothyroxinemia |
| title | Does transient hypothyroxinemia influence metabolic bone disease of prematurity? |
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