Proteomic analysis of cervical vaginal fluid proteins among women in recurrent preterm labor

Abstract Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB)...

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Published in:The journal of maternal-fetal & neonatal medicine 2014-08, Vol.27 (12), p.1183-1188
Main Authors: Lo, Jamie O., Reddy, Ashok P., Wilmarth, Phillip A., Roberts, Victoria H. J., Kinhnarath, Amanda, Snyder, Janice, Rincon, Monica P., Gravett, Michael G., Nagalla, Srinivasa R., Pereira, Leonardo M.
Format: Article
Language:English
Subjects:
Adult
Body Fluids - chemistry
Body Fluids - metabolism
Case-Control Studies
Cervical vaginal fluid
Cervix Uteri - chemistry
Cervix Uteri - metabolism
Female
Gestational Age
Humans
Obstetric Labor, Premature - metabolism
Pregnancy
proteins
Proteins - analysis
Proteins - metabolism
Proteomics
Recurrence
recurrent preterm birth
Vagina - chemistry
Vagina - metabolism
Young Adult
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Summary:Abstract Objective: Proteomic analysis of four cervical-vaginal fluid (CVF) proteins to identify biomarkers of recurrent preterm birth (rPTB) in at-risk women prior to onset of preterm labor. Methods: Nested case control study from 2007 to 2011 of women with prior spontaneous preterm birth(s) (PTB) who underwent serial CVF sampling. Mass spectrometry analysis was used and ELISA analysis was performed to validate candidates. Results: 108 patients were enrolled and 10 cases and 20 gestational age matched controls were analyzed after exclusions. Of 748 CVF proteins identified, 72 had statistically significant (p 
ISSN:1476-7058
1476-4954
DOI:10.3109/14767058.2013.852172