Endocrine Regulation of Neonatal Hypoxia: Role of Glucose, Oxygen, and Epinephrine Supplementation

Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated group...

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Bibliographic Details
Published in:Fetal and pediatric pathology 2011-08, Vol.30 (5), p.338-349
Main Authors: TR, Anju, MS, Nandhu, P, Jes, CS, Paulose
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Endocrine System - physiology
epinephrine
Epinephrine - metabolism
glucose
Glucose - metabolism
Hypoxia, Brain - metabolism
Hypoxia, Brain - physiopathology
insulin
Insulin - metabolism
neonatal hypoxia
oxygen
Oxygen - metabolism
Rats
Rats, Wistar
triiodothyronine
Triiodothyronine - metabolism
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Summary:Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated groups. The insulin concentration was significantly increased with a significant upregulation of receptors in hypoxic neonates. Triiodothyronine content and its receptors were significantly decreased in serum and the hearts of hypoxic neonates. The change in hormonal levels is an adaptive modification of the endocrine system to encounter the stress. The effectiveness of glucose resuscitation to hypoxic neonates was also reported.
ISSN:1551-3815
1551-3823
DOI:10.3109/15513815.2011.587498