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Endocrine Regulation of Neonatal Hypoxia: Role of Glucose, Oxygen, and Epinephrine Supplementation

Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated group...

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Published in:	Fetal and pediatric pathology 2011-08, Vol.30 (5), p.338-349
Main Authors:	TR, Anju, MS, Nandhu, P, Jes, CS, Paulose
Format:	Article
Language:	English
Subjects:	Animals Animals, Newborn Endocrine System - physiology epinephrine Epinephrine - metabolism glucose Glucose - metabolism Hypoxia, Brain - metabolism Hypoxia, Brain - physiopathology insulin Insulin - metabolism neonatal hypoxia oxygen Oxygen - metabolism Rats Rats, Wistar triiodothyronine Triiodothyronine - metabolism
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creator	TR, Anju MS, Nandhu P, Jes CS, Paulose
description	Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated groups. The insulin concentration was significantly increased with a significant upregulation of receptors in hypoxic neonates. Triiodothyronine content and its receptors were significantly decreased in serum and the hearts of hypoxic neonates. The change in hormonal levels is an adaptive modification of the endocrine system to encounter the stress. The effectiveness of glucose resuscitation to hypoxic neonates was also reported.
doi_str_mv	10.3109/15513815.2011.587498
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subjects	Animals Animals, Newborn Endocrine System - physiology epinephrine Epinephrine - metabolism glucose Glucose - metabolism Hypoxia, Brain - metabolism Hypoxia, Brain - physiopathology insulin Insulin - metabolism neonatal hypoxia oxygen Oxygen - metabolism Rats Rats, Wistar triiodothyronine Triiodothyronine - metabolism
title	Endocrine Regulation of Neonatal Hypoxia: Role of Glucose, Oxygen, and Epinephrine Supplementation
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