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Relationships between cellular events and signaling pathways in various pesticide-affected neural cells

Various pesticides are considered hazardous to human health. Of particular concern are potential problems of neurotoxicity associated with their use. Cellular toxicity may manifest as a variety of biological events, such as carcinogenesis (mutagenesis) and/or cell death. Recent reports indicate that...

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Published in:Toxin reviews 2010-05, Vol.29 (2), p.43-50
Main Authors: Kimura, Hirokazu, Tsukagoshi, Hiroyuki, Aoyama, Yoshiko, Nishina, Atsuyoshi, Yamaguchi, Takafumi, Iijima, Akihiro, Kato, Masahiko, Kozawa, Kunihisa
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creator Kimura, Hirokazu
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Kozawa, Kunihisa
description Various pesticides are considered hazardous to human health. Of particular concern are potential problems of neurotoxicity associated with their use. Cellular toxicity may manifest as a variety of biological events, such as carcinogenesis (mutagenesis) and/or cell death. Recent reports indicate that signaling pathways regulate these cellular events. Thus, the toxicity of pesticides in cells may involve modulation of signaling pathways. In this review, we mainly focus on relationships between cellular events and signaling pathways in various pesticide-affected neural cells. Our data and those of related studies suggest that these pesticides affect both the viability and various signaling pathways of neural cells.
doi_str_mv 10.3109/15569543.2010.483533
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects neonicotinoid
neuronal differentiation
organophosphate
PC12 cells
pyrethroid
title Relationships between cellular events and signaling pathways in various pesticide-affected neural cells
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