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Relationships between cellular events and signaling pathways in various pesticide-affected neural cells
Various pesticides are considered hazardous to human health. Of particular concern are potential problems of neurotoxicity associated with their use. Cellular toxicity may manifest as a variety of biological events, such as carcinogenesis (mutagenesis) and/or cell death. Recent reports indicate that...
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Published in: | Toxin reviews 2010-05, Vol.29 (2), p.43-50 |
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cites | cdi_FETCH-LOGICAL-c362t-2d33b9ba3b3a0c7c9a1b1f317e905d3b07b8385a0848d016249d342d9cf78b8a3 |
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container_issue | 2 |
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container_title | Toxin reviews |
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creator | Kimura, Hirokazu Tsukagoshi, Hiroyuki Aoyama, Yoshiko Nishina, Atsuyoshi Yamaguchi, Takafumi Iijima, Akihiro Kato, Masahiko Kozawa, Kunihisa |
description | Various pesticides are considered hazardous to human health. Of particular concern are potential problems of neurotoxicity associated with their use. Cellular toxicity may manifest as a variety of biological events, such as carcinogenesis (mutagenesis) and/or cell death. Recent reports indicate that signaling pathways regulate these cellular events. Thus, the toxicity of pesticides in cells may involve modulation of signaling pathways. In this review, we mainly focus on relationships between cellular events and signaling pathways in various pesticide-affected neural cells. Our data and those of related studies suggest that these pesticides affect both the viability and various signaling pathways of neural cells. |
doi_str_mv | 10.3109/15569543.2010.483533 |
format | article |
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subjects | neonicotinoid neuronal differentiation organophosphate PC12 cells pyrethroid |
title | Relationships between cellular events and signaling pathways in various pesticide-affected neural cells |
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