Cyclopiazonic acid biosynthesis by Aspergillus flavus

Cyclopiazonic acid (CPA) is an indole-tetramic acid mycotoxin produced by some strains of Aspergillus flavus. Characterization of the CPA biosynthesis gene cluster confirmed that formation of CPA is via a three-enzyme pathway. This review examines the structure and organization of the CPA genes, elu...

Full description

Saved in:
Bibliographic Details
Published in:Toxin reviews 2011-08, Vol.30 (2-3), p.79-89
Main Authors: Chang, P.-K., Ehrlich, K.C.
Format: Article
Language:English
Subjects:
Aflatoxin
Aspergillus minisclerotigenes
biocontrol
gene cluster
non-ribosomal peptide synthase
polyketide synthethase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cyclopiazonic acid (CPA) is an indole-tetramic acid mycotoxin produced by some strains of Aspergillus flavus. Characterization of the CPA biosynthesis gene cluster confirmed that formation of CPA is via a three-enzyme pathway. This review examines the structure and organization of the CPA genes, elucidates the specific roles of functional domains of each enzyme in carrying out catalytic conversions leading to CPA production, and delineates the molecular basis for the lack of CPA production by A. flavus strains currently being used in biocontrol of aflatoxin contamination of crops.
ISSN:1556-9543
1556-9551
DOI:10.3109/15569543.2011.576795