Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients

Indoleamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of the kynurenine pathway that degrades L-tryptophan, but a wider range of functions have now been proposed for this enzyme, including antioxidant activity. Our previous study revealed that reduced IDO expression in the placenta induces d...

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Bibliographic Details
Published in:Systems biology in reproductive medicine 2011-08, Vol.57 (4), p.174-178
Main Authors: Nishizawa, Haruki, Suzuki, Machiko, Pryor-Koishi, Kanako, Sekiya, Takao, Tada, Shin, Kurahashi, Hiroki, Udagawa, Yasuhiro
Format: Article
Language:English
Subjects:
8-hydroxy-2'-deoxy-guanosine
Adult
antioxidant
Antioxidants - metabolism
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Female
Humans
indoleamine 2,3-dioxygenase
Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology
Oxidative Stress
placenta
Placenta - enzymology
Placenta - metabolism
pre-eclampsia
Pre-Eclampsia - enzymology
Pre-Eclampsia - etiology
Pregnancy
Trophoblasts - metabolism
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Summary:Indoleamine 2,3-dioxygenase (IDO) is the rate limiting enzyme of the kynurenine pathway that degrades L-tryptophan, but a wider range of functions have now been proposed for this enzyme, including antioxidant activity. Our previous study revealed that reduced IDO expression in the placenta induces defective feto-maternal immuno-tolerance leading to the onset of pre-eclampsia. In our present study, we assessed the effects of low placental IDO activity as an antioxidant. The placental levels of 8-hydroxy-2'-deoxy-guanosine (8-OHdG), a maker for oxidative damage to DNA, were significantly higher in pre-eclamptic than normotensive pregnancies (P 
ISSN:1939-6368
1939-6376
DOI:10.3109/19396368.2011.587590