Role of dendritic cells in immunity against avian coccidiosis

Dendritic cells (DC) are central regulators of immune responses and professional antigen-presenting cells (APCs) with the unique ability to induce both innate immune responses and a highly specific acquired immunity. DC communicates through chemical and mechanical signals in the initiation and maint...

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Bibliographic Details
Published in:World's Poultry Science Journal 2017-12, Vol.73 (4), p.737-746
Main Authors: SHOAIB, M., XIAOKAI, S., UL-HASAN, M., ZAFAR, A., RIAZ, A., UMAR, S., ALI SHAH, M., XIANGRUI, L.
Format: Article
Language:English
Subjects:
Adaptive immunity
Adjuvants
Animal sciences
Antigen-presenting cells
Antigens
avian coccidiosis
Bone marrow
Cell activation
Chickens
Coccidiosis
Dendritic cells
Deoxyribonucleic acid
DNA
Economic impact
Eimeria
Eimeria tenella
Exosomes
Immune response
Immunity
Immunological synapses
Immunology
Infections
Innate immunity
Intestine
Livestock
Lymphocytes
Lymphocytes T
Mechanical stimuli
Medical research
Parasites
Parasitology
Poultry
Regulators
Reviews
Strategy
Strings
Synapses
Turkeys
Vaccines
Veterinary medicine
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Summary:Dendritic cells (DC) are central regulators of immune responses and professional antigen-presenting cells (APCs) with the unique ability to induce both innate immune responses and a highly specific acquired immunity. DC communicates through chemical and mechanical signals in the initiation and maintenance of immune responses. DC forms immunological synapses with T-cells thus pulling T-cells strings and leading to activation of T-cells. Owing to their properties, DC are often called ‘nature's adjuvants’ and thus have become an important component of any vaccination strategy. Coccidiosis is a major intestinal disease caused by Eimeria spp., affecting economically valuable livestock animals such as chickens and turkeys. Economic losses are associated with decreased productivity in afflicted poultry. Vaccination strategies involving DC have been developed owing to the special properties of these cells in coordinating innate and adaptive immune responses. Vaccination of chickens with exosomes isolated from DC containing parasite antigens (Ags) represents a promising alternative strategy to control avian coccidiosis. In recent years, emergence of new chicken DC has opened a new horizon for the development of new vaccines and DC derived vaccine could be a possible strategy to control coccidiosis in field. This review summarises the current state of knowledge of DC and their specific functions in immunity against avian coccidiosis.
ISSN:0043-9339
1743-4777
DOI:10.1017/S0043933917000745