Histaminergic Influence on Vestibular Stimulation-induced Locus Coeruleus Inhibition in Rats

In previous reports we have shown that caloric stimulation (CS) of the vestibular apparatus inhibits locus coeruleus (LC)-noradrenergic neuronal activity in urethane-anaesthetized rats. The present study examined the effect of neural histamine depletion by &#102 -fluoromethylhistidine ( &#10...

Full description

Saved in:
Bibliographic Details
Published in:Acta oto-laryngologica 1998, Vol.118 (533), p.15-18
Main Author: Nishiike, Noriaki Takeda, Atsuhiko Uno, Takeshi Kubo, Atsushi Yamatodani, Shoji Nakamura, Suetaka
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In previous reports we have shown that caloric stimulation (CS) of the vestibular apparatus inhibits locus coeruleus (LC)-noradrenergic neuronal activity in urethane-anaesthetized rats. The present study examined the effect of neural histamine depletion by &#102 -fluoromethylhistidine ( &#102 -FMH) on CS-induced LC inhibition. In &#102 -FMH treated rats, LC neuronal inhibition caused by CS was still observed. This finding indicates that the central histaminergic neuron system does not participate in the CS-induced LC-noradrenergic inhibition. It is suggested that the noradrenergic neuron system is involved in the development of vestibulo-autonomic response, independent of the histaminergic neuron system.
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489850182062