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Electrochemical Response Characteristics and Analytical Application of Papaverine Ion-Selective Membrane Electrodes
The construction and electrochemical response characteristics of poly(vinyl chloride) matrix ion-selective electrodes (ISEs) for papaverine hydrochloride are described. The membranes incorporate ion association complexes of papaverine with tetraphenylborate {[B(C 6 H 5 ) 4 ] − }, picrate {[C 6 H 2 (...
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| Published in: | Analytical letters 2006-01, Vol.39 (2), p.259-273 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| Summary: | The construction and electrochemical response characteristics of poly(vinyl chloride) matrix ion-selective electrodes (ISEs) for papaverine hydrochloride are described. The membranes incorporate ion association complexes of papaverine with tetraphenylborate {[B(C
6
H
5
)
4
]
−
}, picrate {[C
6
H
2
(NO
2
)
3
O]
−
}, tetraiodomercurate [(HgI
4
)]
2−
, tetraiodobismuthate [(BiI
4
)
−
], Reinecke salt {[Cr(NH
3
)
2
(SCN)
4
]
−
} and heteropolycompounds of Keggin structure-molybdophosphoric acid [H
3
(PMo
12
O
40
)], tungstophosphoric acid [H
3
(PW
12
O
40
)], molybdosiliconic acid [H
4
(SiMo
12
O
40
)], and tungstosiliconic acid [H
4
(SiW
12
O
40
)] as electroactive materials for ionometric sensor controls. These ISEs show linear response for papaverine hydrochloride over the range from 1×10
−5
up to 5×10
−2
mol/l with cationic slopes from 42 up to 58 mV per concentration decade. These ISEs exhibit fast response time (up to 1 min), low determination limit (up to 1×10
−5
M), good stability (3-5 weeks) and reasonable selectivity. The ISEs were used for direct potentiometry and potentiometric titration {Na[B(C
6
H
5
)
4
]} of papaverine hydrochloride in pharmaceutical preparations. Results with mean accuracy of 98.6±0.9% of nominal were obtained, which correspond well to data obtained with the European Pharmacopoeial method. |
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| ISSN: | 0003-2719 1532-236X |
| DOI: | 10.1080/00032710500476912 |