ACETYLCHOLINESTERASE ACTIVITY CHANGES ON VISCERAL ORGANS OF VMH LESION-INDUCED OBESE RATS

It is accepted that the tone of the parasympathetic nervous system increases after VMH lesion, whereas the sympathetic tone decreases. To reinforce investigations over outcomes from disturbances of the hypothalamic neuronal systems on peripheral autonomic nerve activity this study determined the ace...

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Bibliographic Details
Published in:International Journal of Neuroscience 2006, Vol.116 (11), p.1295-1302
Main Authors: PAES, ANTONIO M. A., CARNIATTO, SANDRA R., FRANCISCO, FLÁVIO A., BRITO, NILTON A., MATHIAS, PAULO C. F.
Format: Report
Language:English
Subjects:
acetylcolinesterase activity
autonomic nervous system tone
obesity
ventromedial hypothalamic nucleus
visceral organs
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Summary:It is accepted that the tone of the parasympathetic nervous system increases after VMH lesion, whereas the sympathetic tone decreases. To reinforce investigations over outcomes from disturbances of the hypothalamic neuronal systems on peripheral autonomic nerve activity this study determined the acetylcholinesterase (AchE) activity in visceral organs, known as vagal targets, from VMH-lesioned obese rats. It was found that AchE activity was significantly increased in liver, pancreas, and stomach from these animals. However, it was not changed in kidneys, being decreased in spleen. The results suggest that AchE activity is enhanced in vagus innervated tissues to following up the unbalance of the autonomic nervous system as observed in VMH lesion-induced obesity.
ISSN:0020-7454
1543-5245
DOI:10.1080/00207450600920910