Lupus anticoagulant is significantly associated with inflammatory reactions in patients with suspected deep vein thrombosis

Objective. Lupus anticoagulant (LA) and antiphospholipid antibodies (aPL) are suggested as risk factors for development of deep vein thrombosis (DVT) among patients without systemic lupus erythematosus (SLE). Other conditions, e.g. inflammation, are reported to induce LA and it is uncertain whether...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2007, Vol.67 (3), p.270-279
Main Authors: Sidelmann, J. J., SjØland, J. A., Gram, J., Bertelsen, V., Mourits-Andersen, T., Münster, H., Münster, A. M. B., Jespersen, J.
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Anticardiolipin - blood
Antibodies, Anticardiolipin - immunology
Antiphospholipid syndrome
Biomarkers
Blood Coagulation Tests
C-Reactive Protein - analysis
C-Reactive Protein - immunology
deep vein thrombosis
Female
Humans
inflammation
Inflammation - blood
Inflammation - complications
Inflammation - immunology
lupus coagulation inhibitor
Lupus Coagulation Inhibitor - blood
Lupus Coagulation Inhibitor - immunology
Male
Middle Aged
Phlebography
Risk Factors
Venous Thrombosis - complications
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - immunology
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Summary:Objective. Lupus anticoagulant (LA) and antiphospholipid antibodies (aPL) are suggested as risk factors for development of deep vein thrombosis (DVT) among patients without systemic lupus erythematosus (SLE). Other conditions, e.g. inflammation, are reported to induce LA and it is uncertain whether the association between LA and DVT is causal. In this study the associations between aPL, LA and inflammation were investigated in 170 consecutive patients without SLE, but with a tentative diagnosis of DVT. Material and methods. DVT was diagnosed in 64 patients. LA was determined according to the criteria of the International Society of Thrombosis and Haemostasis. The concentration of anticardiolipin (aCL) and 2-glycoprotein I (anti- 2-GPI) antibodies as well as C-reactive protein (CRP) was determined with sensitive and precise methods. Results. LA was demonstrated in 8 patients with DVT and in 10 patients without DVT, relative risk 1.33 (CI: 0.55-3.18). No significant association was observed between aCL or anti- 2-GPI and DVT. Patients suffering from DVT had significantly higher concentrations of CRP than patients without DVT. However, CRP was also significantly higher in patients positive for LA than in patients without LA irrespective of the presence of DVT (p
ISSN:0036-5513
1502-7686
DOI:10.1080/00365510601038992