The 13C-urea breath test as a predictor of intragastric bacterial load and severity of Helicobacter pylori gastritis

Background: The urea breath test (UBT) has been proposed as the most accurate test for diagnosing Helicobacter pylori infection. The aim of this work was to evaluate the accuracy of the UBT and to compare the results with histologic and endoscopic findings in H. pylori infected patients. Methods: On...

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Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 1998-02, Vol.58 (1), p.19-28
Main Authors: Perri, F., Clemente, R., Pastore, M., Quitadamo, M., Festa, V., Bisceglia, M., Li Bergoli, M., Lauriola, G., Leandro, G., Ghoos, Y., Rutgeerts, P, Andriulli, A.
Format: Article
Language:English
Subjects:
Adult
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Biological and medical sciences
Biopsy
Breath Test Helicobacter Pylori Urea Breath Test
Breath Tests
Carbon Isotopes
Female
Gastric Mucosa - microbiology
Gastric Mucosa - pathology
Gastritis - microbiology
Gastroscopy
Helicobacter Infections - diagnosis
Helicobacter Infections - microbiology
Helicobacter pylori - isolation & purification
Helicobacter pylori - metabolism
Human bacterial diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Urea - analysis
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Summary:Background: The urea breath test (UBT) has been proposed as the most accurate test for diagnosing Helicobacter pylori infection. The aim of this work was to evaluate the accuracy of the UBT and to compare the results with histologic and endoscopic findings in H. pylori infected patients. Methods: One-hundred-and-seventy-two consecutive dyspeptic outpatients were studied by means of endoscopy (with histology and culture), UBT (75 mg 13C-urea), and serology. Gastritis was classified in accordance with the Sydney criteria. In H. pylori positive patients, the bacterial load was assessed semiquantitatively, the number of bacteria in histologic specimens being counted. UBT results were expressed either as percentage cumulative dose of 13CO2 excreted at 1 h (CD60) or delta over baseline at 30' (DOB30). Results
ISSN:0036-5513
1502-7686
DOI:10.1080/00365519850186797