Expression of Inducible Nitric Oxide Synthase in Colorectal Cancer and Its Association with Prognosis

Background: The expression of inducible nitric oxide synthase (iNOS) has been reported to be altered in a number of tumours, but its role in tumour biology is still unclear. Methods: iNOS was studied in a series of 157 colorectal carcinoma patients and its relation to tumour grade, stage, cell cycle...

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Published in:Scandinavian journal of gastroenterology 2000, Vol.35 (11), p.1204-1211
Main Authors: ROPPONEN, K. M, KELLOKOSKI, J. K, LIPPONEN, P. K, ESKELINEN, M. J, ALANNE, L, ALHAVA, E. M, KOSMA, V. M
Format: Article
Language:English
Subjects:
Adenocarcinoma - enzymology
Adenocarcinoma - mortality
Biological and medical sciences
Biomarkers, Tumor - analysis
Cell Cycle Proteins - analysis
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - mortality
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Nitric Oxide Synthase - biosynthesis
Nitric Oxide Synthase Type II
Prognosis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Rate
Tumors
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Summary:Background: The expression of inducible nitric oxide synthase (iNOS) has been reported to be altered in a number of tumours, but its role in tumour biology is still unclear. Methods: iNOS was studied in a series of 157 colorectal carcinoma patients and its relation to tumour grade, stage, cell cycle regulators, cell proliferation as well as survival was assessed. Results: iNOS intensity was moderate or intense in 37% of the tumours. iNOS intensity and percentage of positive cells were higher in Dukes A and B tumours than in Dukes C and D tumours, and low iNOS expression intensity was related to high histological grade. iNOS expression correlated positively with cell cycle regulators p21 and AP-2. There was also a high iNOS expression intensity and high fraction of iNOS positive cells in tumours with a high amount of tumour infiltrating lymphocytes (TILs). The cancer related survival was significantly lower among patients with a low signal for iNOS and low iNOS percentage in tumour epithelium. In multivariate analysis iNOS was not an independent prognostic factor. Conclusions: These results suggest that iNOS has a protective role in colorectal carcinogenesis, but further studies are required to establish the clinical significance of iNOS in colorectal cancer.
ISSN:0036-5521
1502-7708
DOI:10.1080/003655200750056709