Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs

Background: Glucagon-like peptide-2 is formed from proglucagon in the intestinal L-cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1 (glucagon-like peptide-1), which in addition acts to inhibit gastric motility (enterogastrone effect) by inhibiting central parasy...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1998, Vol.33 (8), p.828-832
Main Authors: Wøjdemann, M, Wettergren, A, Hartmann, B, Holst, J J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Digestive system
Gastric Emptying
Gastrointestinal Hormones - administration & dosage
Gastrointestinal Hormones - physiology
Glucagon-Like Peptide 1
Glucagon-Like Peptide 2
Hypoglycemia - physiopathology
Medical sciences
Peptides - administration & dosage
Peptides - physiology
Pharmacology. Drug treatments
Postprandial Period
Pyloric Antrum - physiology
Pyloric Antrum - physiopathology
Swine
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Summary:Background: Glucagon-like peptide-2 is formed from proglucagon in the intestinal L-cells and is secreted postprandially in parallel with the insulinotropic hormone GLP-1 (glucagon-like peptide-1), which in addition acts to inhibit gastric motility (enterogastrone effect) by inhibiting central parasympathetic outflow. GLP-2 has no effect on the endocrine pancreas. We here tested the hypothesis that GLP-2 acts as an enterogastrone. Methods: Fourteen anesthetized pigs with their splanchnic nerves cut were subjected to insulin hypoglycemia, and force transducers were sutured to the antrum to record motility. GLP-2 was infused intravenously in doses from 1 to 6 pmol/kg/min after the onset of antral motility in response to hypoglycemia. Results
ISSN:0036-5521
1502-7708
DOI:10.1080/00365529850171486