Rate of Carriage of Serratia marcescens in Patients with and without Evidence of Infection

The epidemiology of Serratia marcescens is poorly understood. We designed a study to investigate carriage sites of the organism, and possible modes of transmission of infection. Using Sorbitol?MacConkey agar with colistin 200 IU/ml and MacConkey agar with a 10 m g colistin disc we performed cultures...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2001, Vol.33 (11), p.822-826
Main Authors: BYRNE, Alison H, HERRA, Celine M, AUCKEN, Hazel, KEANE, Conor T
Format: Article
Language:English
Subjects:
Bacterial diseases
Biological and medical sciences
Carrier State
Feces - microbiology
Human bacterial diseases
Humans
Infectious diseases
Intensive Care Units
Ireland - epidemiology
Mass Screening
Medical sciences
Miscellaneous
Nose - microbiology
Pharynx - microbiology
Serotyping
Serratia Infections - epidemiology
Serratia Infections - microbiology
Serratia marcescens
Serratia marcescens - isolation & purification
Urine - microbiology
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Summary:The epidemiology of Serratia marcescens is poorly understood. We designed a study to investigate carriage sites of the organism, and possible modes of transmission of infection. Using Sorbitol?MacConkey agar with colistin 200 IU/ml and MacConkey agar with a 10 m g colistin disc we performed cultures from various sites in patients already infected with S. marcescens. Over the same period of time we also investigated all patients in the intensive care unit (ICU) for colonization with the agent. Environmental screening was performed in the ICU only. Of 37 infected patients, 65% demonstrated carriage at a second site and 43% at multiple sites. Throat carriage was found in 59%, faecal carriage in 42%, nasal carriage in 31% and urinary carriage in 22%. Carriage over several weeks was found in 22%. Of 40 ICU patients, 10% demonstrated nasal and/or throat carriage. Environmental screening yielded 4 isolates. All ICU patient strains and a strain from the ICU bedpan macerator were O14:K14 with similar random amplified polymorphic DNA types. These results show that patients with S. marcescens infection are likely to carry the organism at multiple sites and that carriage may be prolonged. A significant level of carriage was also found in non-infected patients in a unit where the organism was prevalent.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540110077385