Efficient Synthesis of Biologically Active (±)-Confluentin and (±)-Daurichromenic Acid

One-step synthesis of biologically active (±)-confluentin is described from commercially available orcinol with trans,trans-farnesal in the presence of ethylenediamine diacetate as a catalyst. Further conversion of synthetic confluentin to highly potent anti-HIV agent, (±)-daurichromenic acid, is ac...

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Bibliographic Details
Published in:Synthetic communications 2006-11, Vol.36 (22), p.3329-3334
Main Authors: Rok Lee, Yong, Wang, Xue, Kyun Noh, Seok, Seok Lyoo, Won
Format: Article
Language:English
Subjects:
anti-HIV agent
Confluentin
daurichromenic acid
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Summary:One-step synthesis of biologically active (±)-confluentin is described from commercially available orcinol with trans,trans-farnesal in the presence of ethylenediamine diacetate as a catalyst. Further conversion of synthetic confluentin to highly potent anti-HIV agent, (±)-daurichromenic acid, is accomplished by formylation and oxidation in two steps.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910600941224