Rapid Method of Converting Primary Amides to Nitriles and Nitriles to Primary Amides by ZnCl2 using Microwaves under Different Reaction Conditions

A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl 2 in aqueous acetonitrile and their regeneration using ZnCl 2 -H 2 O-THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to co...

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Bibliographic Details
Published in:Synthetic communications 2007-05, Vol.37 (9), p.1545-1550
Main Authors: Manjula, Krishnappa, Afzal Pasha, Mohamed
Format: Article
Language:English
Subjects:
microwave irradiation
nitriles
primary amides
ZnCl
Online Access:Get full text
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Summary:A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl 2 in aqueous acetonitrile and their regeneration using ZnCl 2 -H 2 O-THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to completion within a minute.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910701230147