Rapid Method of Converting Primary Amides to Nitriles and Nitriles to Primary Amides by ZnCl2 using Microwaves under Different Reaction Conditions

A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl 2 in aqueous acetonitrile and their regeneration using ZnCl 2 -H 2 O-THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to co...

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Published in:Synthetic communications 2007-05, Vol.37 (9), p.1545-1550
Main Authors: Manjula, Krishnappa, Afzal Pasha, Mohamed
Format: Article
Language:English
Subjects:
microwave irradiation
nitriles
primary amides
ZnCl
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container_title Synthetic communications
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creator Manjula, Krishnappa
Afzal Pasha, Mohamed
description A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl 2 in aqueous acetonitrile and their regeneration using ZnCl 2 -H 2 O-THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to completion within a minute.
doi_str_mv 10.1080/00397910701230147
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source Taylor and Francis Science and Technology Collection
subjects microwave irradiation
nitriles
primary amides
ZnCl
title Rapid Method of Converting Primary Amides to Nitriles and Nitriles to Primary Amides by ZnCl2 using Microwaves under Different Reaction Conditions
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