Efficient Synthesis of 1-Aryl-1H-indazole Derivatives via Copper(I)-Catalyzed Intramolecular Amination Reaction

A copper(I)-catalyzed intramolecular amination reaction using CuI, KOH, and 1,4-dioxane at 105°C for the preparation of 1-aryl-1H-indazole derivatives was described. The method was applied to a wide scope of substrates and afforded indazole products in high yields.

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Bibliographic Details
Published in:Synthetic communications 2008-01, Vol.38 (2), p.249-254
Main Authors: Liu, Rui, Zhu, Yongming, Qin, Liena, Ji, Shunjun
Format: Article
Language:English
Subjects:
1,10-phenanthroline
arylhydrazones
copper(I) iodide
indazole
intramolecular amination
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Description
Summary:A copper(I)-catalyzed intramolecular amination reaction using CuI, KOH, and 1,4-dioxane at 105°C for the preparation of 1-aryl-1H-indazole derivatives was described. The method was applied to a wide scope of substrates and afforded indazole products in high yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910701750250