Simple Synthesis of P1P2-Diadenosine 5′-Pyrophosphate

Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromor...

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Bibliographic Details
Published in:Synthetic communications 2008-09, Vol.38 (19), p.3260-3269
Main Authors: Millo, Enrico, Zocchi, Elena, Galatini, Andrea, Benatti, Umberto, Damonte, Gianluca
Format: Article
Language:English
Subjects:
Coenzymes
diadenosine
morpholidate
pyrophosphate
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Summary:Pyrophosphate-linked coenzymes play essential roles in several biochemical systems. Symmetrical diadenosine-5′-pyrophosphate (Ap2A) has been synthesized from adenosine-5′-phosphate in virtually quantitative yield. The simple procedure is carried out in anhydrous pyridine using adenosine phosphoromorpholidate and adenosine monophosphate bis-(tri-n-butylammonium salt) as coupling reagents.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802116583