Efficient Method of Synthesis of N,N′-Disubstituted Ureas/Thioureas by a Zinc Chloride Catalyzed Thermal Reaction

Symmetrically N,N′-disubstituted ureas/thioureas were synthesized by heating amines or phenyl hydrazine and urea/thiourea on a preheated hot plate at 80-85°C under solvent-free conditions in the presence of a catalytic amount of ZnCl 2 as a catalyst. The protocol has the advantages of not using toxi...

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Bibliographic Details
Published in:Synthetic communications 2009-07, Vol.39 (16), p.2928-2934
Main Authors: Pasha, M. A., Madhusudana Reddy, M. B.
Format: Article
Language:English
Subjects:
Disubstituted ureas/thioureas
solvent-free reaction
thermal condition
ZnCl
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Summary:Symmetrically N,N′-disubstituted ureas/thioureas were synthesized by heating amines or phenyl hydrazine and urea/thiourea on a preheated hot plate at 80-85°C under solvent-free conditions in the presence of a catalytic amount of ZnCl 2 as a catalyst. The protocol has the advantages of not using toxic phosgene and other hazardous substrates or organic solvents. Increased reaction rate, good yield, and a simple workup procedure are involved.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802697467