A Facile One-Pot Conversion of Aldehydes into Nitriles

A facile one-pot synthesis of nitriles starting with aldehydes has been developed employing hydroxylamine hydrochloride in dimethylsulfoxide at 100°C.

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Bibliographic Details
Published in:Synthetic communications 2009-09, Vol.39 (20), p.3601-3606
Main Authors: Chill, Samuel T., Mebane, Robert C.
Format: Article
Language:English
Subjects:
Aldehyde
aldoxime
dehydration
nitrile
tandem reaction
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Description
Summary:A facile one-pot synthesis of nitriles starting with aldehydes has been developed employing hydroxylamine hydrochloride in dimethylsulfoxide at 100°C.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910902788174