Asymmetric Synthesis of (S,S,S)-2-Aza-bicyclo-[3.3.0]-octane-3-carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril

An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.

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Bibliographic Details
Published in:Synthetic communications 2011-03, Vol.41 (8), p.1186-1191
Main Authors: Kondaiah, G. C. M., Vivekanandareddy, M., Reddy, L. Amarnath, Anurkar, Smita V., Gurav, V. M., Ravikumar, M., Bhattacharya, Apurba, Bandichhor, Rakeshwar
Format: Article
Language:English
Subjects:
(S)-1-Amino-2-methoxy methylpyrrolidine (SAMP)
Acids
angiotensin converting enzyme (ACE) inhibitor
asymmetric synthesis
chiral auxiliary
enantiomerically pure ramipril
Hypertension
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Description
Summary:An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911003798757