An Improved Synthesis of Oxazinones Using Molecular Sieves

Oxazinones are important chiral reagents in the synthesis of both proteinogenic and nonproteinogenic amino acids. Large scale synthesis of oxazinones has been a problem. The use of molecular sieves in the final step to remove ethanol has helped to obtain the cyclized product in three hours.

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Bibliographic Details
Published in:Synthetic communications 1997-12, Vol.27 (24), p.4355-4360
Main Authors: Iyer, Mani S., Yan, Changren, Kowalczyk, Russel, Shone, Robert, Ager, David, Schaad, David R.
Format: Article
Language:English
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Description
Summary:Oxazinones are important chiral reagents in the synthesis of both proteinogenic and nonproteinogenic amino acids. Large scale synthesis of oxazinones has been a problem. The use of molecular sieves in the final step to remove ethanol has helped to obtain the cyclized product in three hours.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919708005061