An Improved Synthesis of Oxazinones Using Molecular Sieves

Oxazinones are important chiral reagents in the synthesis of both proteinogenic and nonproteinogenic amino acids. Large scale synthesis of oxazinones has been a problem. The use of molecular sieves in the final step to remove ethanol has helped to obtain the cyclized product in three hours.

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Published in:Synthetic communications 1997-12, Vol.27 (24), p.4355-4360
Main Authors: Iyer, Mani S., Yan, Changren, Kowalczyk, Russel, Shone, Robert, Ager, David, Schaad, David R.
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Language:English
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cited_by cdi_FETCH-LOGICAL-c344t-1d7b4709e8b164dd9169b47068d58946a979cd0957ef0858e4be61db91be7f43
cites cdi_FETCH-LOGICAL-c344t-1d7b4709e8b164dd9169b47068d58946a979cd0957ef0858e4be61db91be7f43
container_end_page 4360
container_issue 24
container_start_page 4355
container_title Synthetic communications
container_volume 27
creator Iyer, Mani S.
Yan, Changren
Kowalczyk, Russel
Shone, Robert
Ager, David
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description Oxazinones are important chiral reagents in the synthesis of both proteinogenic and nonproteinogenic amino acids. Large scale synthesis of oxazinones has been a problem. The use of molecular sieves in the final step to remove ethanol has helped to obtain the cyclized product in three hours.
doi_str_mv 10.1080/00397919708005061
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title An Improved Synthesis of Oxazinones Using Molecular Sieves
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