REACTIVE EXTRACTION OF BETA-LACTAM ANTIBIOTICS: IR SPECTROSCOPIC STUDIES

Infrared spectroscope study on reactive extraction of Cephalosporin-C (CPC) and 6-Aminopenicillanic acid (6-APA) with secondary and tertiary amines and a quaternary amine salt as the extractants in butyl acetate as the diluent has been reported. The study aims at analysing the chemical interaction i...

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Bibliographic Details
Published in:Chemical engineering communications 2000-01, Vol.180 (1), p.107-126
Main Authors: BORA, MADAN M., DUTTA, NARENDRA N., TOSH, B., BHATTACHARYA, KRISHNA G.
Format: Article
Language:English
Subjects:
Aliquat-336
Amberlite LA-2
beta-lactam
IR spectra
Reactive extraction
Trioctylamine
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Summary:Infrared spectroscope study on reactive extraction of Cephalosporin-C (CPC) and 6-Aminopenicillanic acid (6-APA) with secondary and tertiary amines and a quaternary amine salt as the extractants in butyl acetate as the diluent has been reported. The study aims at analysing the chemical interaction involved in the complexation of the molecules with the extract-ant and the reaction stoichiometry. Amberlite LA-2, Trioctylamine and Aliquat-336 (Tricaprylyl methyl ammonium chloride) were used as the extractants. The results of experimental extraction equilibrium study and spectroscopic analysis indicate the formation of (1:1) complex vie ion-exchange reaction of CPC and 6-APA with Aliquat-336. The ion-pair extraction with Amberlite LA-2 and Trioctylamine exhibited non-stoichiometric complexation in accordance with experimental observation on equilibrium relationship
ISSN:0098-6445
1563-5201
DOI:10.1080/00986440008912204