Potassium dichromate-induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes

It has been reported that potassium dichromate-induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular f...

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Bibliographic Details
Published in:Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2009, Vol.32 (1), p.21-25
Main Authors: Becerra-Torres, Sergio Lucio, Luisa Rodríguez-Vázquez, María, Ernestina Medina-Ramírez, Iliana, Jaramillo-Juárez, Fernando
Format: Article
Language:English
Subjects:
Alanine aminopeptidase
Animals
Biological and medical sciences
CD13 Antigens - drug effects
CD13 Antigens - metabolism
CD13 Antigens - urine
Chemical and industrial products toxicology. Toxic occupational diseases
Environmental Pollutants - toxicity
Gamma-glutamyl transpeptidase
gamma-Glutamyltransferase - drug effects
gamma-Glutamyltransferase - metabolism
gamma-Glutamyltransferase - urine
Injections, Intraperitoneal
Kidney
Male
Medical sciences
Metals and various inorganic compounds
Nephrotoxicity
Potassium dichromate
Potassium Dichromate - toxicity
Rats
Rats, Wistar
Toxicology
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Summary:It has been reported that potassium dichromate-induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular fluids. The aim of this study was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes. Our results show that the administration of a single intraperitoneal dose of potassium dichromate decreased the activity of such enzymes in urine.
ISSN:0148-0545
1525-6014
DOI:10.1080/01480540802416190