Potassium dichromate-induced changes on urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes

• Published in: Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2009, Vol.32 (1), p.21-25
• Main Authors: Becerra-Torres, Sergio Lucio, Luisa Rodríguez-Vázquez, María, Ernestina Medina-Ramírez, Iliana, Jaramillo-Juárez, Fernando
• Format: Article
• Language: English
• Subjects: Alanine aminopeptidase; Animals; Biological and medical sciences; CD13 Antigens - drug effects; CD13 Antigens - metabolism; CD13 Antigens - urine; Chemical and industrial products toxicology. Toxic occupational diseases; Environmental Pollutants - toxicity; Gamma-glutamyl transpeptidase; gamma-Glutamyltransferase - drug effects; gamma-Glutamyltransferase - metabolism; gamma-Glutamyltransferase - urine; Injections, Intraperitoneal; Kidney; Male; Medical sciences; Metals and various inorganic compounds; Nephrotoxicity; Potassium dichromate; Potassium Dichromate - toxicity; Rats; Rats, Wistar; Toxicology
• ISSN: 0148-0545; 1525-6014
• DOI: 10.1080/01480540802416190

It has been reported that potassium dichromate-induced nephrotoxicity is evidenced by diminution in creatinine clearance, increase in urinary protein, and structural damage to the proximal tubules. Damage to tissue often leads to the release of enzymes from the injured cells into the extracellular fluids. The aim of this study was to establish whether potassium dichromate induces changes in the urinary-specific activities of gamma-glutamyl transpeptidase and alanine aminopeptidase enzymes. Our results show that the administration of a single intraperitoneal dose of potassium dichromate decreased the activity of such enzymes in urine.