EFFICACY OF INTRAUTERINE INSEMINATION WITHOUT OVARIAN HYPERSTIMULATION FOR MALE OR CERVICAL FACTOR IN WOMEN AGED 40 OR OVER

The efficacy of intrauterine insemination (IUI) for male or cervical factor by age of female partner was determined in a retrospective analysis. Patients who underwent IUI therapy for cervical and/or male factor (n = 281) were classified by age at first IUI cycle: or =40 years (n = 49). The indicat...

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Bibliographic Details
Published in:Archives of andrology 2000, Vol.44 (3), p.193-196
Main Authors: CHECK, J. H, LURIE, D, PEYMER, M, KATSOFF, D, LONG, R
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biological and medical sciences
Birth control
Female
Gynecology. Andrology. Obstetrics
Humans
Insemination, Artificial - methods
Insemination, Artificial - standards
Intrauterine Insemination Ovarian Stimulation
Male
Medical sciences
Middle Aged
Ovulation Induction
Pregnancy
Pregnancy Outcome
Retrospective Studies
Sterility. Assisted procreation
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Summary:The efficacy of intrauterine insemination (IUI) for male or cervical factor by age of female partner was determined in a retrospective analysis. Patients who underwent IUI therapy for cervical and/or male factor (n = 281) were classified by age at first IUI cycle: or =40 years (n = 49). The indication for IUI was cervical factor if a postcoital test failed to show sperm with good forward progression at time of mature follicle; male factor was diagnosed if the semen analysis demonstrated either low count, low motility, antisperm antibodies, or subnormal hypoosmotic swelling test. Intrauterine insemination was performed in either natural cycles or following ovarian stimulation for the treatment of anovulation or follicular maturation defects. Cumulative probability of ongoing pregnancy (viable at end of first trimester) following 3 cycles of IUI was evaluated. Cumulative probability of ongoing pregnancy following 3 cycles of IUI was 28.2% for the younger group and 0.0% for the older group. The age groups did not differ in terms of infertility history, use of ovarian stimulation, or baseline semen parameters. Thus, the treatment of male and/or cervical factor by IUI is ineffective for women > or =40 years.
ISSN:0955-3002
0148-5016
1362-3095
1521-0375
DOI:10.1080/014850100262164