Magnetic Extraction, Detection, and Isotope Analysis of Metal Ions Using Surface Modified Microspheres for Lab-on-a-Chip Applications

Liquid-liquid extraction and ion-exchange chromatography are efficient methods for sequestration of metal ions, but these methods are poorly suitable for microfluidic miniaturization. Here we examine several methods for rapid extraction, fluorometric detection, and the subsequent isotope analysis of...

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Bibliographic Details
Published in:Separation science and technology 2010-01, Vol.45 (2), p.186-197
Main Authors: Shkrob, Ilya A., Kaminski, Michael D., Rahimian, Kamyar, Derzon, Mark S.
Format: Article
Language:English
Subjects:
antenna effect
Fluorometers
fluorometry
ion-exchange chromatography
isotope analysis
Isotopes
Lanthanides
Liquid-liquid extraction
magnetic separations
Metal ions
microfluidics
Microspheres
Miniaturization
Platforms
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Summary:Liquid-liquid extraction and ion-exchange chromatography are efficient methods for sequestration of metal ions, but these methods are poorly suitable for microfluidic miniaturization. Here we examine several methods for rapid extraction, fluorometric detection, and the subsequent isotope analysis of lanthanide ions sequestered on surface modified magnetic microspheres as a versatile platform for chemical manipulation. The assays involve immobilization of a mixed-ligand complex of luminescent lanthanide ions at the surface of polystyrene microspheres. Using the ion-exchange properties of these microspheres, this scheme can be extended to the detection of nonluminescent ions.
ISSN:0149-6395
1520-5754
DOI:10.1080/01496390903423733