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Effect of dietary phytosterols on rat tissue lipids
The present study was designed to examine the incorporation of phytosterols (PS) in membranes and tissues of rats fed a diet containing 2% PS in the presence of 0.2% cholic acid for 22 days. The control diet contained 12 mg PS/100 g compared with 2,012 mg/100 g. Liver, kidney, testis, and prostate m...
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| Published in: | Nutrition and cancer 1997, Vol.29 (3), p.212-216 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c448t-798790788448cf97aa89866bda09bc3765322e078fdc103612ef891341a662883 |
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| cites | cdi_FETCH-LOGICAL-c448t-798790788448cf97aa89866bda09bc3765322e078fdc103612ef891341a662883 |
| container_end_page | 216 |
| container_issue | 3 |
| container_start_page | 212 |
| container_title | Nutrition and cancer |
| container_volume | 29 |
| creator | Awad, A.B. (State University of New York at Buffalo, Buffalo, NY.) Garcia, M.D Fink, C.S |
| description | The present study was designed to examine the incorporation of phytosterols (PS) in membranes and tissues of rats fed a diet containing 2% PS in the presence of 0.2% cholic acid for 22 days. The control diet contained 12 mg PS/100 g compared with 2,012 mg/100 g. Liver, kidney, testis, and prostate microsomes, plasma, and epididymal fat pads were examined for sterols. Fatty acid composition and phospholipid pattern were also examined in some tissues. The PS diet resulted in a fivefold increase in plasma PS compared with controls. PS was found to accumulate in adipose tissue and liver microsomes in rats fed the PS-supplemented diet. There was no effect of PS incorporation on microsomal cholesterol content, except in the testes, in which dietary PS reduced cholesterol content by 25%. Dietary PS increased 20:4n-6 and 22:5n-3 fatty acids in membranes of the liver, testis, and prostate but decreased 16:1 in liver microsomes. PS incorporation had no effect on the phospholipid pattern of the liver and testis |
| doi_str_mv | 10.1080/01635589709514626 |
| format | article |
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(State University of New York at Buffalo, Buffalo, NY.) ; Garcia, M.D ; Fink, C.S</creator><creatorcontrib>Awad, A.B. (State University of New York at Buffalo, Buffalo, NY.) ; Garcia, M.D ; Fink, C.S</creatorcontrib><description>The present study was designed to examine the incorporation of phytosterols (PS) in membranes and tissues of rats fed a diet containing 2% PS in the presence of 0.2% cholic acid for 22 days. The control diet contained 12 mg PS/100 g compared with 2,012 mg/100 g. Liver, kidney, testis, and prostate microsomes, plasma, and epididymal fat pads were examined for sterols. Fatty acid composition and phospholipid pattern were also examined in some tissues. The PS diet resulted in a fivefold increase in plasma PS compared with controls. PS was found to accumulate in adipose tissue and liver microsomes in rats fed the PS-supplemented diet. There was no effect of PS incorporation on microsomal cholesterol content, except in the testes, in which dietary PS reduced cholesterol content by 25%. Dietary PS increased 20:4n-6 and 22:5n-3 fatty acids in membranes of the liver, testis, and prostate but decreased 16:1 in liver microsomes. PS incorporation had no effect on the phospholipid pattern of the liver and testis</description><identifier>ISSN: 0163-5581</identifier><identifier>EISSN: 1532-7914</identifier><identifier>DOI: 10.1080/01635589709514626</identifier><identifier>PMID: 9457741</identifier><identifier>CODEN: NUCADQ</identifier><language>eng</language><publisher>Philadelphia, PA: Taylor & Francis Group</publisher><subject>ACIDE GRAS ; ACIDOS GRASOS ; ADIPOSE TISSUES ; ANIMAL MODELS ; Animal Nutritional Physiological Phenomena ; Animals ; Biological and medical sciences ; BLOOD PLASMA ; CAMPESTEROL ; Carcinogenesis, carcinogens and anticarcinogens ; CHOLESTEROL ; Cohort Studies ; COLESTEROL ; COMPLEMENT ALIMENTAIRE ; CYTOPLASMIC ORGANELLES ; DIET ; DIETA ; EPIDIDYMIS ; EXPERIMENTACION ; EXPERIMENTATION ; FATTY ACIDS ; Fatty Acids - analysis ; Fatty Acids - classification ; FITOSTEROLES ; FOIE ; Foods and miscellaneous ; FOSFOLIPIDOS ; HIGADO ; KIDNEYS ; LIVER ; Liver - chemistry ; Liver - pathology ; Male ; Medical sciences ; MEMBRANES ; MICROSOMES ; Microsomes, Liver - chemistry ; Microsomes, Liver - pathology ; MODELE ANIMAL ; MODELOS ANIMALES ; ORGANITE CELLULAIRE ; ORGANULOS CITOPLASMICOS ; PHOSPHATIDE ; PHOSPHOLIPIDS ; PHYTOSTEROL ; PHYTOSTEROLS ; Phytosterols - administration & dosage ; Phytosterols - pharmacokinetics ; PLASMA SANGUIN ; PLASMA SANGUINEO ; PROSTATA ; PROSTATE ; Prostate - chemistry ; Prostate - pathology ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; REGIME ALIMENTAIRE ; REIN ; RINONES ; Sterols - analysis ; Sterols - classification ; SUPLEMENTOS ; SUPPLEMENTS ; TEJIDO ADIPOSO ; TESTES ; TESTICULE ; TESTICULOS ; Testis - chemistry ; Testis - pathology ; TISSU ADIPEUX ; Tumors</subject><ispartof>Nutrition and cancer, 1997, Vol.29 (3), p.212-216</ispartof><rights>Copyright Taylor & Francis Group, LLC 1997</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-798790788448cf97aa89866bda09bc3765322e078fdc103612ef891341a662883</citedby><cites>FETCH-LOGICAL-c448t-798790788448cf97aa89866bda09bc3765322e078fdc103612ef891341a662883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2110160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9457741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awad, A.B. (State University of New York at Buffalo, Buffalo, NY.)</creatorcontrib><creatorcontrib>Garcia, M.D</creatorcontrib><creatorcontrib>Fink, C.S</creatorcontrib><title>Effect of dietary phytosterols on rat tissue lipids</title><title>Nutrition and cancer</title><addtitle>Nutr Cancer</addtitle><description>The present study was designed to examine the incorporation of phytosterols (PS) in membranes and tissues of rats fed a diet containing 2% PS in the presence of 0.2% cholic acid for 22 days. The control diet contained 12 mg PS/100 g compared with 2,012 mg/100 g. Liver, kidney, testis, and prostate microsomes, plasma, and epididymal fat pads were examined for sterols. Fatty acid composition and phospholipid pattern were also examined in some tissues. The PS diet resulted in a fivefold increase in plasma PS compared with controls. PS was found to accumulate in adipose tissue and liver microsomes in rats fed the PS-supplemented diet. There was no effect of PS incorporation on microsomal cholesterol content, except in the testes, in which dietary PS reduced cholesterol content by 25%. Dietary PS increased 20:4n-6 and 22:5n-3 fatty acids in membranes of the liver, testis, and prostate but decreased 16:1 in liver microsomes. PS incorporation had no effect on the phospholipid pattern of the liver and testis</description><subject>ACIDE GRAS</subject><subject>ACIDOS GRASOS</subject><subject>ADIPOSE TISSUES</subject><subject>ANIMAL MODELS</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BLOOD PLASMA</subject><subject>CAMPESTEROL</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>CHOLESTEROL</subject><subject>Cohort Studies</subject><subject>COLESTEROL</subject><subject>COMPLEMENT ALIMENTAIRE</subject><subject>CYTOPLASMIC ORGANELLES</subject><subject>DIET</subject><subject>DIETA</subject><subject>EPIDIDYMIS</subject><subject>EXPERIMENTACION</subject><subject>EXPERIMENTATION</subject><subject>FATTY ACIDS</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - classification</subject><subject>FITOSTEROLES</subject><subject>FOIE</subject><subject>Foods and miscellaneous</subject><subject>FOSFOLIPIDOS</subject><subject>HIGADO</subject><subject>KIDNEYS</subject><subject>LIVER</subject><subject>Liver - chemistry</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEMBRANES</subject><subject>MICROSOMES</subject><subject>Microsomes, Liver - chemistry</subject><subject>Microsomes, Liver - pathology</subject><subject>MODELE ANIMAL</subject><subject>MODELOS ANIMALES</subject><subject>ORGANITE CELLULAIRE</subject><subject>ORGANULOS CITOPLASMICOS</subject><subject>PHOSPHATIDE</subject><subject>PHOSPHOLIPIDS</subject><subject>PHYTOSTEROL</subject><subject>PHYTOSTEROLS</subject><subject>Phytosterols - administration & dosage</subject><subject>Phytosterols - pharmacokinetics</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>PROSTATA</subject><subject>PROSTATE</subject><subject>Prostate - chemistry</subject><subject>Prostate - pathology</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>REGIME ALIMENTAIRE</subject><subject>REIN</subject><subject>RINONES</subject><subject>Sterols - analysis</subject><subject>Sterols - classification</subject><subject>SUPLEMENTOS</subject><subject>SUPPLEMENTS</subject><subject>TEJIDO ADIPOSO</subject><subject>TESTES</subject><subject>TESTICULE</subject><subject>TESTICULOS</subject><subject>Testis - chemistry</subject><subject>Testis - pathology</subject><subject>TISSU ADIPEUX</subject><subject>Tumors</subject><issn>0163-5581</issn><issn>1532-7914</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEYhIMotVZ_gAdhD-JtNe9mNx_gRUr9AMGD9hzSbKIru01Nsmj_vSmt9VDQUwjzzDDvIHQK-BIwx1cYKKkqLhgWFZS0oHtoCBUpciag3EfDlZ4nAA7RUQjvGGMGhA_QQJQVYyUMEZlYa3TMnM3qxkTll9nibRldiMa7NmRunnkVs9iE0JusbRZNHY7RgVVtMCebd4Smt5OX8X3--HT3ML55zHVZ8pg6cCYw4zz9tBVMKS44pbNaYTHThNFUtDAJsLUGTCgUxnIBpARFacE5GaGLde7Cu4_ehCi7JmjTtmpuXB8kExVJWJVAWIPauxC8sXLhmy7dIgHL1VByZ6jkOduE97PO1FvHZpmkn290FbRqrVdz3YQtVgCkTJyw6zXWzK3znfp0vq1lVMvW-R8P-asF-9e-45LxK_72t8pJ9eoTOH0GkShGywKTbyGym34</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Awad, A.B. 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(State University of New York at Buffalo, Buffalo, NY.) ; Garcia, M.D ; Fink, C.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-798790788448cf97aa89866bda09bc3765322e078fdc103612ef891341a662883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>ACIDE GRAS</topic><topic>ACIDOS GRASOS</topic><topic>ADIPOSE TISSUES</topic><topic>ANIMAL MODELS</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BLOOD PLASMA</topic><topic>CAMPESTEROL</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>CHOLESTEROL</topic><topic>Cohort Studies</topic><topic>COLESTEROL</topic><topic>COMPLEMENT ALIMENTAIRE</topic><topic>CYTOPLASMIC ORGANELLES</topic><topic>DIET</topic><topic>DIETA</topic><topic>EPIDIDYMIS</topic><topic>EXPERIMENTACION</topic><topic>EXPERIMENTATION</topic><topic>FATTY ACIDS</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - classification</topic><topic>FITOSTEROLES</topic><topic>FOIE</topic><topic>Foods and miscellaneous</topic><topic>FOSFOLIPIDOS</topic><topic>HIGADO</topic><topic>KIDNEYS</topic><topic>LIVER</topic><topic>Liver - chemistry</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEMBRANES</topic><topic>MICROSOMES</topic><topic>Microsomes, Liver - chemistry</topic><topic>Microsomes, Liver - pathology</topic><topic>MODELE ANIMAL</topic><topic>MODELOS ANIMALES</topic><topic>ORGANITE CELLULAIRE</topic><topic>ORGANULOS CITOPLASMICOS</topic><topic>PHOSPHATIDE</topic><topic>PHOSPHOLIPIDS</topic><topic>PHYTOSTEROL</topic><topic>PHYTOSTEROLS</topic><topic>Phytosterols - administration & dosage</topic><topic>Phytosterols - pharmacokinetics</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>PROSTATA</topic><topic>PROSTATE</topic><topic>Prostate - chemistry</topic><topic>Prostate - pathology</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>REGIME ALIMENTAIRE</topic><topic>REIN</topic><topic>RINONES</topic><topic>Sterols - analysis</topic><topic>Sterols - classification</topic><topic>SUPLEMENTOS</topic><topic>SUPPLEMENTS</topic><topic>TEJIDO ADIPOSO</topic><topic>TESTES</topic><topic>TESTICULE</topic><topic>TESTICULOS</topic><topic>Testis - chemistry</topic><topic>Testis - pathology</topic><topic>TISSU ADIPEUX</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awad, A.B. (State University of New York at Buffalo, Buffalo, NY.)</creatorcontrib><creatorcontrib>Garcia, M.D</creatorcontrib><creatorcontrib>Fink, C.S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition and cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awad, A.B. (State University of New York at Buffalo, Buffalo, NY.)</au><au>Garcia, M.D</au><au>Fink, C.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dietary phytosterols on rat tissue lipids</atitle><jtitle>Nutrition and cancer</jtitle><addtitle>Nutr Cancer</addtitle><date>1997</date><risdate>1997</risdate><volume>29</volume><issue>3</issue><spage>212</spage><epage>216</epage><pages>212-216</pages><issn>0163-5581</issn><eissn>1532-7914</eissn><coden>NUCADQ</coden><abstract>The present study was designed to examine the incorporation of phytosterols (PS) in membranes and tissues of rats fed a diet containing 2% PS in the presence of 0.2% cholic acid for 22 days. The control diet contained 12 mg PS/100 g compared with 2,012 mg/100 g. Liver, kidney, testis, and prostate microsomes, plasma, and epididymal fat pads were examined for sterols. Fatty acid composition and phospholipid pattern were also examined in some tissues. The PS diet resulted in a fivefold increase in plasma PS compared with controls. PS was found to accumulate in adipose tissue and liver microsomes in rats fed the PS-supplemented diet. There was no effect of PS incorporation on microsomal cholesterol content, except in the testes, in which dietary PS reduced cholesterol content by 25%. Dietary PS increased 20:4n-6 and 22:5n-3 fatty acids in membranes of the liver, testis, and prostate but decreased 16:1 in liver microsomes. PS incorporation had no effect on the phospholipid pattern of the liver and testis</abstract><cop>Philadelphia, PA</cop><pub>Taylor & Francis Group</pub><pmid>9457741</pmid><doi>10.1080/01635589709514626</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-5581 |
| ispartof | Nutrition and cancer, 1997, Vol.29 (3), p.212-216 |
| issn | 0163-5581 1532-7914 |
| language | eng |
| recordid | cdi_informaworld_taylorfrancis_310_1080_01635589709514626 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | ACIDE GRAS ACIDOS GRASOS ADIPOSE TISSUES ANIMAL MODELS Animal Nutritional Physiological Phenomena Animals Biological and medical sciences BLOOD PLASMA CAMPESTEROL Carcinogenesis, carcinogens and anticarcinogens CHOLESTEROL Cohort Studies COLESTEROL COMPLEMENT ALIMENTAIRE CYTOPLASMIC ORGANELLES DIET DIETA EPIDIDYMIS EXPERIMENTACION EXPERIMENTATION FATTY ACIDS Fatty Acids - analysis Fatty Acids - classification FITOSTEROLES FOIE Foods and miscellaneous FOSFOLIPIDOS HIGADO KIDNEYS LIVER Liver - chemistry Liver - pathology Male Medical sciences MEMBRANES MICROSOMES Microsomes, Liver - chemistry Microsomes, Liver - pathology MODELE ANIMAL MODELOS ANIMALES ORGANITE CELLULAIRE ORGANULOS CITOPLASMICOS PHOSPHATIDE PHOSPHOLIPIDS PHYTOSTEROL PHYTOSTEROLS Phytosterols - administration & dosage Phytosterols - pharmacokinetics PLASMA SANGUIN PLASMA SANGUINEO PROSTATA PROSTATE Prostate - chemistry Prostate - pathology RAT RATA RATS Rats, Sprague-Dawley REGIME ALIMENTAIRE REIN RINONES Sterols - analysis Sterols - classification SUPLEMENTOS SUPPLEMENTS TEJIDO ADIPOSO TESTES TESTICULE TESTICULOS Testis - chemistry Testis - pathology TISSU ADIPEUX Tumors |
| title | Effect of dietary phytosterols on rat tissue lipids |
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