Tubuloreticular Structures in Different Types of Myositis: Implications for Pathogenesis

In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cel...

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Bibliographic Details
Published in:Ultrastructural pathology 2008-01, Vol.32 (4), p.123-126
Main Authors: Bronner, Irene M., Hoogendijk, Jessica E., Veldman, Henk, Ramkema, Marja, van den Bergh Weerman, Marius A., Rozemuller, Annemieke J. M., de Visser, Marianne
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - pathology
Biopsy
Capillaries - ultrastructure
dermatomyositis
Dermatomyositis - pathology
Endothelium, Vascular - ultrastructure
Female
Humans
Inclusion Bodies - ultrastructure
Lupus Erythematosus, Discoid - pathology
Male
Microscopy, Electron, Transmission - methods
Microtubules - ultrastructure
Middle Aged
Mixed Connective Tissue Disease - pathology
Muscle, Skeletal - blood supply
Muscle, Skeletal - pathology
polymyositis
Scleroderma, Systemic - pathology
Sjogren's Syndrome - pathology
tubuloreticular structures
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Summary:In dermatomyositis (DM) there is strong histopathological evidence of a microvascular pathogenesis, including endothelial microtubular inclusions. In nonspecific myositis, perimysial and perivascular infiltrates in the muscle biopsy similar to DM are found. Microtubular inclusions in endothelial cells were systematically searched for and found in 4 of the 20 muscle biopsies of nonspecific myositis patients (20%). Three had a CTD (SLE, scleroderma, and Sjögren syndrome). Ten patients with DM and 5 patients with sporadic inclusion body myositis served as positive and negative controls, respectively.
ISSN:0191-3123
1521-0758
DOI:10.1080/01913120802209379