Crystalloid Inclusions in Brain Macrophages and Hemopoietic Tissue in GFAP-IL3 Mice Resemble Inclusions Identified in Multiple Sclerosis

Crystalloid inclusions or "pole bodies" observed in brain macrophages in human demyelinating disease represent a morphological enigma. Similar inclusions were detected in brain macrophages from the GFAP-IL3 mouse, a transgenic murine model for macrophage mediated demyelination. Mice also s...

Full description

Saved in:
Bibliographic Details
Published in:Ultrastructural pathology 1999, Vol.23 (5), p.285-297
Main Authors: Powell, H C, Garrett, R S, Muehlenbachs, A, Brett, F M, Campbell, I L
Format: Article
Language:English
Subjects:
Animals
Bone Marrow Cells - metabolism
Bone Marrow Cells - ultrastructure
Cathepsin
Chaperonins
Demyelination
Lysozyme
Macrophage
Pseudo-pseudo Gaucher Cells
Cathepsins - metabolism
Cerebellum - metabolism
Cerebellum - pathology
Chaperonin 10 - metabolism
Crystallization
Disease Models, Animal
Glial Fibrillary Acidic Protein - biosynthesis
Glial Fibrillary Acidic Protein - genetics
Inclusion Bodies - metabolism
Inclusion Bodies - ultrastructure
Interleukin-3 - biosynthesis
Interleukin-3 - genetics
Macrophages - metabolism
Macrophages - ultrastructure
Mice
Mice, Transgenic
Multiple Sclerosis - etiology
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
Muramidase - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Crystalloid inclusions or "pole bodies" observed in brain macrophages in human demyelinating disease represent a morphological enigma. Similar inclusions were detected in brain macrophages from the GFAP-IL3 mouse, a transgenic murine model for macrophage mediated demyelination. Mice also showed inclusions in hematopoietic tissue. They appear to be related to phagocytosis and secretion, respectively, as evidenced by the fact that in phagocytosing cells they often merged with lysozomes and that affected cells showed empty channels open to the interstitium. Based on ultrastructural and immunolocalization studies using chaperonin-10, lysozyme, and cathepsin the authors suggest that these inclusions are consistent with phagocytosis-related secretory products. This study may provide insight into the nature and significance of similar macrophage inclusions recently identified in multiple sclerosis.
ISSN:0191-3123
1521-0758
DOI:10.1080/019131299281437