Sustained release of neuron-specific enolase to serum in amateur boxers

Primary objective: We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma. Research design: Observational case-control study. Methods and procedures: A panel of serum biomarkers w...

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Bibliographic Details
Published in:Brain injury 2009-01, Vol.23 (9), p.723-726
Main Authors: Zetterberg, Henrik, Tanriverdi, Fatih, Unluhizarci, Kursad, Selcuklu, Ahmet, Kelestimur, Fahrettin, Blennow, Kaj
Format: Article
Language:English
Subjects:
Adolescent
Adult
biomarkers
Biomarkers - blood
Boxing
Boxing - injuries
Brain Injuries - blood
Brain Injuries - enzymology
brain injury
Case-Control Studies
Humans
Male
neuron-specific enolase
Phosphopyruvate Hydratase - blood
Psychiatry
Psykiatri
Statistics, Nonparametric
Young Adult
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Summary:Primary objective: We assess the potential of a panel of serum biomarkers to identify chronic neuronal injury in amateur boxers as compared to healthy controls without any history of head trauma. Research design: Observational case-control study. Methods and procedures: A panel of serum biomarkers was measured by a novel biochip array technique on the Evidence Investigator. Serum samples were taken after a 2-month period of nonparticipation in boxing. Main outcomes and results: Boxers had higher serum levels of neuron-specific enolase (NSE, median [range] 11 [2.3-41] ng/mL) than controls (4.8 [0.78-27] ng/mL, p = 0.014) but unchanged levels of the other brain damage biomarker candidates, S-100B, brain-derived neurotrophic factor and heart-type fatty acid binding protein. Conclusions: The more than doubled median serum level of NSE in boxers after an extended resting period suggests that repetitive head trauma results in sustained release of this brain-specific protein to the peripheral circulation.
ISSN:0269-9052
1362-301X
1362-301X
DOI:10.1080/02699050903120399