Increased expression of CD23 in rheumatoid synovitis

Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 a...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2000, Vol.29 (3), p.154-159
Main Authors: HUISSOON, A. P, EMERY, P, BACON, P. A, GORDON, J, SALMON, M
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
Inflammatory joint diseases
Integrin alphaXbeta2 - metabolism
Ligands
Macrophage-1 Antigen - metabolism
Macrophages - metabolism
Male
Medical sciences
Middle Aged
Receptors, Complement 3d - metabolism
Receptors, IgE - metabolism
Synovial Fluid - metabolism
Synovitis - etiology
Synovitis - metabolism
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Summary:Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p
ISSN:0300-9742
1502-7732
DOI:10.1080/030097400750002012