Increased expression of CD23 in rheumatoid synovitis

Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 a...

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Published in:Scandinavian journal of rheumatology 2000, Vol.29 (3), p.154-159
Main Authors: HUISSOON, A. P, EMERY, P, BACON, P. A, GORDON, J, SALMON, M
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
Inflammatory joint diseases
Integrin alphaXbeta2 - metabolism
Ligands
Macrophage-1 Antigen - metabolism
Macrophages - metabolism
Male
Medical sciences
Middle Aged
Receptors, Complement 3d - metabolism
Receptors, IgE - metabolism
Synovial Fluid - metabolism
Synovitis - etiology
Synovitis - metabolism
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container_end_page 159
container_issue 3
container_start_page 154
container_title Scandinavian journal of rheumatology
container_volume 29
creator HUISSOON, A. P
EMERY, P
BACON, P. A
GORDON, J
SALMON, M
description Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p
doi_str_mv 10.1080/030097400750002012
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P ; EMERY, P ; BACON, P. A ; GORDON, J ; SALMON, M</creator><creatorcontrib>HUISSOON, A. P ; EMERY, P ; BACON, P. A ; GORDON, J ; SALMON, M</creatorcontrib><description>Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p&lt;0.01). Synovial CD23 was found to be expressed principally on macrophages. While little CD21 expression was detected, CD11b and CD11c were both expressed at high levels, particularly on macrophages. Conclusions. Soluble CD23 is present in high levels in RA synovial fluid. Macrophages appear to be the principal source. Macrophages also express ligands for sCD23, and may therefore also be the targets of this potent pro-inflammatory molecule.</description><identifier>ISSN: 0300-9742</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.1080/030097400750002012</identifier><identifier>PMID: 10898066</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - metabolism ; Biological and medical sciences ; Diseases of the osteoarticular system ; Female ; Humans ; Inflammatory joint diseases ; Integrin alphaXbeta2 - metabolism ; Ligands ; Macrophage-1 Antigen - metabolism ; Macrophages - metabolism ; Male ; Medical sciences ; Middle Aged ; Receptors, Complement 3d - metabolism ; Receptors, IgE - metabolism ; Synovial Fluid - metabolism ; Synovitis - etiology ; Synovitis - metabolism</subject><ispartof>Scandinavian journal of rheumatology, 2000, Vol.29 (3), p.154-159</ispartof><rights>2000 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2000</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-4d324175219d5c1d129cbb60ab44fc98cf7af82973b2b33888d7a274a0ec7f363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1431897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10898066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUISSOON, A. P</creatorcontrib><creatorcontrib>EMERY, P</creatorcontrib><creatorcontrib>BACON, P. A</creatorcontrib><creatorcontrib>GORDON, J</creatorcontrib><creatorcontrib>SALMON, M</creatorcontrib><title>Increased expression of CD23 in rheumatoid synovitis</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p&lt;0.01). Synovial CD23 was found to be expressed principally on macrophages. While little CD21 expression was detected, CD11b and CD11c were both expressed at high levels, particularly on macrophages. Conclusions. Soluble CD23 is present in high levels in RA synovial fluid. Macrophages appear to be the principal source. Macrophages also express ligands for sCD23, and may therefore also be the targets of this potent pro-inflammatory molecule.</description><subject>Arthritis, Rheumatoid - complications</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Integrin alphaXbeta2 - metabolism</subject><subject>Ligands</subject><subject>Macrophage-1 Antigen - metabolism</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Complement 3d - metabolism</subject><subject>Receptors, IgE - metabolism</subject><subject>Synovial Fluid - metabolism</subject><subject>Synovitis - etiology</subject><subject>Synovitis - metabolism</subject><issn>0300-9742</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwAyxQFohdYPxIbEuwQOUpIbGBdeQ4tuoqiYudAP17UrUIEFJXsznnzsxF6BjDOQYBF0ABJGcAPAMAApjsoDHOgKScU7KLxisgHQgyQgcxzgeISS730WjQpYA8HyP22OpgVDRVYj4XwcTofJt4m0xvCE1cm4SZ6RvVeVclcdn6d9e5eIj2rKqjOdrMCXq9u32ZPqRPz_eP0-unVDOadSmrKGGYZwTLKtO4wkTqssxBlYxZLYW2XFlBJKclKSkVQlRcEc4UGM0tzekEna1zF8G_9SZ2ReOiNnWtWuP7WHBMqGA5H0CyBnXwMQZji0VwjQrLAkOx6qr439UgnWzS-7Ix1S9lXc4AnG4AFbWqbVCtdvGHYxQLuVp-tcZca31o1IcPdVV0aln78O3QrXdc_vFnRtXdTKtgirnvQzs0vO2NL0krlHs</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>HUISSOON, A. 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A ; GORDON, J ; SALMON, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-4d324175219d5c1d129cbb60ab44fc98cf7af82973b2b33888d7a274a0ec7f363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Arthritis, Rheumatoid - complications</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Integrin alphaXbeta2 - metabolism</topic><topic>Ligands</topic><topic>Macrophage-1 Antigen - metabolism</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Complement 3d - metabolism</topic><topic>Receptors, IgE - metabolism</topic><topic>Synovial Fluid - metabolism</topic><topic>Synovitis - etiology</topic><topic>Synovitis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUISSOON, A. P</creatorcontrib><creatorcontrib>EMERY, P</creatorcontrib><creatorcontrib>BACON, P. A</creatorcontrib><creatorcontrib>GORDON, J</creatorcontrib><creatorcontrib>SALMON, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUISSOON, A. P</au><au>EMERY, P</au><au>BACON, P. A</au><au>GORDON, J</au><au>SALMON, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of CD23 in rheumatoid synovitis</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>2000</date><risdate>2000</risdate><volume>29</volume><issue>3</issue><spage>154</spage><epage>159</epage><pages>154-159</pages><issn>0300-9742</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Objective. Soluble (s)CD23 is a potent macrophage stimulator. High levels of this molecule have been reported in rheumatoid arthritis (RA) serum. We investigated the expression of CD23 and its ligands in rheumatoid synovial fluid and cells. Methods. Levels of sCD23, and cellular expression of CD23 and its ligands CD21, CD11b, and CD11c were measured in synovial fluid (SF) of RA patients and in blood of RA patients and controls. Results. SF contained higher levels of sCD23 than either rheumatoid or normal sera (median 4.8, 3.16,and 1.13 ng/ml respectively, p&lt;0.01). Synovial CD23 was found to be expressed principally on macrophages. While little CD21 expression was detected, CD11b and CD11c were both expressed at high levels, particularly on macrophages. Conclusions. Soluble CD23 is present in high levels in RA synovial fluid. Macrophages appear to be the principal source. Macrophages also express ligands for sCD23, and may therefore also be the targets of this potent pro-inflammatory molecule.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>10898066</pmid><doi>10.1080/030097400750002012</doi><tpages>6</tpages></addata></record>
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
Inflammatory joint diseases
Integrin alphaXbeta2 - metabolism
Ligands
Macrophage-1 Antigen - metabolism
Macrophages - metabolism
Male
Medical sciences
Middle Aged
Receptors, Complement 3d - metabolism
Receptors, IgE - metabolism
Synovial Fluid - metabolism
Synovitis - etiology
Synovitis - metabolism
title Increased expression of CD23 in rheumatoid synovitis
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