Expression of 5-HT3A receptors in cells of the immune system

There is evidence from both human and animal research that 5-hydroxytryptamine3 (5-HT3) receptor antagonists, particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects including the expression of 5-HT3 receptors in cells of the immune...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 2004-01, Vol.33 (S119), p.9-11
Main Authors: Fiebich, BL, Akundi, RS, Seidel, M, Geyer, V, Haus, U, Müller, W, Stratz, T, Candelario-Jalil, E
Format: Article
Language:English
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Summary:There is evidence from both human and animal research that 5-hydroxytryptamine3 (5-HT3) receptor antagonists, particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects including the expression of 5-HT3 receptors in cells of the immune system have not yet been investigated in detail. Therefore, we investigated the expression of the 5-HT3A receptor in primary human monocytes, chondrocytes, T-cells, dendritic cells, and synovial tissue. We found that 5-HT3A receptors are expressed in monocytes, chondrocytes, T-cells, and synovial tissue but not in dendritic cells. Our data show that 5-HT3A receptors are widely expressed in cells of the immune system and that they might play an important role in inflammatory events and in the observed antiphlogistic effects of 5-HT3 receptor antagonists.
ISSN:0300-9742
1502-7732
DOI:10.1080/03009740410006952