Lower Extremity Motor Function and Disability in Mild Cognitive Impairment

• Published in: Experimental aging research 2007-07, Vol.33 (3), p.355-371
• Main Authors: Boyle, P. A., Wilson, R. S., Buchman, A. S., Aggarwal, N. T., Tang, Y., Arvanitakis, Z., Kelly, J., Bennett, D. A.
• Format: Article
• Language: English
• Subjects: Activities of Daily Living - classification; Adult and adolescent clinical studies; Adult. Elderly; Aged; Aged, 80 and over; Biological and medical sciences; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - psychology; Cognition Disorders - diagnosis; Cognition Disorders - psychology; Dementia, Vascular - diagnosis; Dementia, Vascular - psychology; Developmental psychology; Disability Evaluation; Female; Fundamental and applied biological sciences. Psychology; Gait; Geriatrics; Humans; Isometric Contraction; Lower Extremity; Male; Medical sciences; Mental Status Schedule; Middle Aged; Muscle Strength; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurologic Examination; Neurology; Neuropsychological Tests; Organic mental disorders. Neuropsychology; Peripheral Nervous System Diseases - diagnosis; Peripheral Nervous System Diseases - psychology; Postural Balance; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Statistics as Topic
• ISSN: 0361-073X; 1096-4657
• DOI: 10.1080/03610730701319210

Recent findings suggest that lower extremity motor dysfunction may be a feature of mild cognitive impairment (MCI), but little is known about the nature and significance of lower extremity motor dysfunction in MCI. The aim of this study was to examine the extent to which MCI is associated with impaired gait, balance, and strength and to examine the relation of lower extremity function to disability among persons with MCI in the Rush Memory and Aging Project, a clinical-pathologic study of common chronic conditions of old age. In a series of analyses adjusted for age, sex, and education, individuals with MCI exhibited more impaired gait and balance than individuals without cognitive impairment. Because vascular factors can contribute to lower extremity motor dysfunction, the authors repeated the initial analyses including terms for vascular risk factors and vascular disease, and the associations between MCI and lower extremity motor dysfunction persisted. Moreover, among those with MCI, impairments in gait and balance were associated with an increased likelihood of disability. These findings suggest that lower extremity motor dysfunction is common and contributes to disability in MCI, but lower extremity motor dysfunction in MCI does not appear to be explained by the vascular factors examined in this study.