Development of Naftifine Hydrochloride Alcohol-Free Niosome Gel

Marketed topical gels of the antifungal drug naftifine hydrochloride contain 50% alcohol as cosolvent. Repeated exposure to alcohol could be detrimental to skin. The aim of this study is to develop an alcohol-free niosome gel containing 1% naftifine hydrochloride. Niosomes were prepared and formulat...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2009-05, Vol.35 (5), p.631-637
Main Authors: Barakat, Heba S., Darwish, Inas A., El-Khordagui, Labiba K., Khalafallah, Nawal M.
Format: Article
Language:English
Subjects:
alcohol-free
Allylamine - administration & dosage
Allylamine - analogs & derivatives
Allylamine - chemistry
Antifungal Agents - administration & dosage
Antifungal Agents - chemistry
Biological and medical sciences
Cellulose - analogs & derivatives
Chemistry, Pharmaceutical
Drug Stability
Excipients
Gels
General pharmacology
Liposomes
Medical sciences
Microscopy, Electron, Scanning
naftifine hydrochloride
niosomes
Organophosphates - chemistry
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polysorbates
Spectrophotometry, Ultraviolet
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Summary:Marketed topical gels of the antifungal drug naftifine hydrochloride contain 50% alcohol as cosolvent. Repeated exposure to alcohol could be detrimental to skin. The aim of this study is to develop an alcohol-free niosome gel containing 1% naftifine hydrochloride. Niosomes were prepared and formulation variables were optimized to achieve maximum entrapment coupled with stability. Maximum drug entrapment and niosome stability entailed imparting a negative charge to the vesicles where entrapment efficiency reached 50%. Niosomes were incorporated into a hydroxyethylcellulose gel. The final gel contained a total drug concentration of 1% (wt wt) half of which was entrapped in the niosomes. The results suggest the potential usefulness of the niosome gel.
ISSN:0363-9045
1520-5762
DOI:10.1080/03639040802498864